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A challenging case of a pituitary macroadenoma and toxic thyroid adenoma with inappropriate TSH secretion.
Endocrinol Diabetes Metab Case Rep
April 2024
Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand Johannesburg, Johannesburg, Gauteng, South Africa.
Summary: Thyroid-stimulating hormone-secreting pituitary adenomas (TSHomas) are rare, accounting for less than 1% of all pituitary adenomas. We present a case of hyperthyroidism secondary to a likely TSHoma and coexisting functional thyroid adenoma. Laboratory errors and familial abnormalities in thyroid function tests were ruled out, and a diagnosis of the toxic thyroid adenoma was confirmed on a thyroid uptake scan.
View Article and Find Full Text PDFAn Aggressive Plurihormonal Pituitary Adenoma With Thyrotropin, Growth Hormone, and Prolactin Excess.
JCEM Case Rep
March 2023
Department of Medicine, Hospital Melaka, 75400 Melaka, Malaysia.
A 31-year-old gentleman presented with clinical hyperthyroidism, goiter, bitemporal hemianopia, and discordant thyroid function test. The high α-subunit and absence of throtropin (thyroid-stimulating hormone; TSH) response to thyrotropin-releasing hormone stimulation indicated a TSH-secreting pituitary tumor. Elevation in prolactin and growth hormone as well as secondary hypogonadism were also observed.
View Article and Find Full Text PDFRadioiodine Ablation of Thyroid Remnants in Patients with Graves' Orbitopathy.
J Nucl Med
April 2023
Department of Nuclear Medicine, University Hospital Essen, Essen, Germany
Our purpose was to assess response after ablation of thyroid remnants (ATR) with radioactive iodine therapy in patients with unstable Graves' orbitopathy (GO) after subtotal thyroidectomy. Thirty patients with mild ( = 4, 13%), moderate-to-severe ( = 25, 83%), or very severe GO ( = 1, 3%) were analyzed in this retrospective study. The primary endpoint was the improvement of GO-related symptoms as assessed by clinical activity scores, NOSPECS, and soft-tissue inflammation scores at 3 and 12 mo after ATR.
View Article and Find Full Text PDFPreparation, characterization, and in vivo biodistribution study of intranasal I-clonazepam-loaded phospholipid magnesome as a promising brain delivery system.
Eur J Pharm Sci
February 2022
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, P.O. Box 11562, Cairo, Egypt; Department of Pharmaceutics and Industrial Pharmacy, School of Pharmacy, New Giza University, Giza, Egypt.
Objective: Clonazepam (CP) is a potent long-acting nitrobenzodiazepine derivative that could be used for targeting peripheral benzodiazepine receptors. Phospholipid magnesome is a new vesicular nanosystem recently developed for brain targeting. Improving the uptake of I-CP to the brain might be effective for the diagnosis and/or radiotherapy of certain brain diseases and/or tumors.
View Article and Find Full Text PDFFormation and occurrence of disinfection byproducts of benzodiazepine drug estazolam in drinking water of Beijing.
Sci Total Environ
January 2022
Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Control and Prevention, Beijing 100013, China; College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Road, Beijing 100193, China. Electronic address:
Estazolam (EZ) is a long-acting benzodiazepine (BZD) drug with high clinical consumption in China to treat anxiety, depression and other syndromes. Recently, it has been found as a leading potentially inappropriate medication among hospitalized elderly patients, increasing the risk of falls. It is discharged into the aquatic environment after use and has been frequently detected, ultimately affecting the safety of drinking water.
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