Am J Ophthalmol Case Rep
Central Michigan University College of Medicine, Saginaw, MI, USA.
Published: March 2022
Purpose: To describe 2 cases of recalcitrant fungal keratitis successfully treated with intracameral Amphotericin B.
Methods: Interventional case series.
Results: A 59-year-old female and a 41-year-old male each presented with fungal keratitis, caused by spp. and spp. respectively. Both cases were unresponsive to topical antifungals, causing persistent discomfort and decreased vision. The two patients subsequently received a single dose of intracameral amphotericin B (ICAMB) 10mcg/0.1 mL, in addition to continued topical natamycin. Both patients had remarkable results following ICAMB, with best corrected visual acuity of 20/20 and full corneal reepithelization following treatment.
Conclusions: We report 2 cases of intractable fungal keratitis that benefited from intracameral injections of amphotericin B. This route of delivery appears to be very effective because the medication is delivered directly to the deeper layers of the cornea, where fungal infections tend to reside, and where topical and systemic routes have difficulty accessing.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818535 | PMC |
http://dx.doi.org/10.1016/j.ajoc.2022.101369 | DOI Listing |
Asia Pac J Ophthalmol (Phila)
January 2025
Ophthalmology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Am J Ophthalmol Case Rep
December 2024
Department of Ophthalmology, University of Tokyo Hospital, 7-3-1, Bunkyo-ku, Tokyo, Japan.
Purpose: This report presents a case of fungal keratitis treated with penetrating keratoplasty using a cryopreserved cornea, highlighting the successful maintenance of corneal transparency post infection resolution.
Observations: A 57-year-old man complaining of pain in the right eye was referred to our hospital. Although diagnosed with fungal keratitis, his corneal scraping indicated the presence of , and he was unresponsive to voriconazole, micafungin, and pimaricin treatments.
Braz J Microbiol
January 2025
Federal University of Ceará Fortaleza, Ceará, Brazil.
Fusarium keratitis (FK) is an important clinical condition that can lead to blindness and eye loss, and is most commonly caused by the Fusarium solani species complex (FSSC). This study evaluated the susceptibility of planktonic cells and biofilms of FSSC (n = 7) and non-FSSC (n = 7) isolates obtained from patients with keratitis from a semi-arid tropical region to amphotericin B (AMB), natamycin (NAT), voriconazole (VRZ), efinaconazole (EFZ), and luliconazole (LCZ). Analysis of clinical data showed that trauma was the most common risk factor for FK patients.
View Article and Find Full Text PDFBMC Infect Dis
January 2025
Liaoning Provincial Key Laboratory of Cornea and Ocular Surface Diseases, Liaoning Provincial Optometry Technology Engineering Research Center, The Third People's Hospital of Dalian, Dalian Municipal Eye Hospital, Dalian Municipal Cancer Hospital, No. 40, Qianshan Road, Ganjingzi District, Dalian, Liaoning, China.
Background: Conjunctival sporotrichosis is a rare fungal infection, typically presenting as granulomatous lesions. Its manifestations can be atypical, particularly in immunosuppressed patients. Here, we present a rare case of a Mooren's ulcer patient with bulbar conjunctival Sporotrichosis presenting as a salmon-pink tumor.
View Article and Find Full Text PDFAsia Pac J Ophthalmol (Phila)
January 2025
Department of Ophthalmology and Visual Science, Kochi Medical School, Kochi University, Nankoku City, Kochi, Japan.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!
© LitMetric 2025. All rights reserved.