Pharmacologic and non-pharmacologic labor pain management techniques in a resource-limited setting: A systematic review.

Background: Despite improvement in pain management programs, labor pain is mostly ignored especially in low and middle-income countries.

Methods: The aim of this study is to establish a clear clinical working guideline for labor pain management in resource limited settings. This systematic review is conducted in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline 2020. After formulating clear criteria for the evidences to be included an appropriate method of searching was conducted by using the Pub Med, Google scholar and Cochrane library using the following MeSH terms: ('Parenteral opioids' AND' Labor pain', 'Labor' AND 'Pain management, 'Non-pharmacologic methods 'AND 'Labor pain', 'Labor pain management AND massage therapy). The study quality of literatures was categorized based on WHO 2011 level of evidence and degree of recommendation. Final conclusions and recommendations are done with the analysis of risk and benefits of alternative management strategies for non-regional techniques of labor pain management. The study is registered with research registry unique identifying number (UIN) of 1267 "https://www.researchregistry.com/browse-the-registry#registryofsystematicreviewsmeta-analyses/." and the study is moderate based on AMSTAR 2 quality assessment criteria/https://amstar.ca/Amstar_Checklist.php.

Discussion: Combined forms of Non-pharmacologic and selected low dose pharmacologic approaches of labor pain management, provides significant benefits to women and their infants. During provision of labor analgesia complications may happen and the service provider should involve in the management of those complications.

Conclusion: This study has a paramount importance to practice the most reliable, available and cost effective method of labor analgesia.