Myopericytoma (MPC) is a rare, benign tumour often presenting as a cutaneous growth commonly in the lower extremities. It is distinguished by its concentric layering of spindle shaped myoid appearing cells perivascularly. These cells diagnostically stain positive to alpha smooth-muscle actin and rarely positive to desmin stain. This case study reviews the presentation of a 56-year-old male with a slow-growing, pre-tibial lesion developing over a 7-8 year period. This lesion was asymptomatic and demonstrated vascular involvement on ultrasound scan. This lesion measured 19 × 15 × 9 mm histologically and contained bland spindle cells surrounding vessels that interestingly stained positive to both alpha smooth-muscle actin and desmin. The histological findings in correlation to clinical presentation and imaging led to a diagnosis of MPC.
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http://dx.doi.org/10.1093/jscr/rjac021 | DOI Listing |
Metastasis is the leading cause of mortality in breast cancer, with lung metastasis being particularly detrimental. Identification of the processes determining metastatic organotropism could enable the development of approaches to prevent and treat breast cancer metastasis. Here, we found that lung-tropic and non-lung-tropic breast cancer cells differ in their response to sialic acids, affecting the sialylation of surface proteins.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA.
Background: Aging is associated with disruptions in non-rapid eye movement (NREM) sleep and memory decline. Cerebral small vessel disease (CSVD) increases with age and is associated with clinical sleep disturbance, but little is known about its relationship with local expression of NREM sleep. Here, we explore associations between CSVD burden, memory, and local electroencephalography (EEG) measures during NREM sleep in older adults.
View Article and Find Full Text PDFBackground: SAAs represent a promising biomarker of Lewy Body disease (LBD), with high sensitivity (87.3%, 95%CI: 0.755-0.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
UCL Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK.
Background: Connectome-based models of disease propagation are used to probe mechanisms of pathology spread in neurodegenerative disease. We present our network spreading model toolbox that allows the user to compare model fits across different models and parameters. We apply the toolbox to assess whether local amyloid levels affect production of pathological tau.
View Article and Find Full Text PDFBackground: Alzheimer's and Synuclein diseases are characterized by distinct biomarkers and frequently co-occur, suggesting potential interactions between their pathological pathways. This study leverages amyloid and tau PET imaging, along with CSF Phosphorylated tau (P-tau) and alpha-synuclein measurements from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to investigate the impact of co-pathology on cognitive functions.
Method: We conducted an analysis using ADNI data (Table 1) from the 2024-01-08 download, including results from the CSF alpha-Synuclein Seed Amplification Assay (SAA, 2023-09-29 release, 1637 samples out of 1638 records included in the analysis).
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