AI Article Synopsis
- The ketogenic diet (KD) is found to be an effective non-drug treatment for children with drug-resistant epilepsy, aiming to reduce seizure frequency.
- A systematic review identified eight randomized controlled trials, revealing that nearly 48% of kids experienced a significant decrease in seizures after starting the diet.
- The analysis demonstrated that children on the KD are 5.6 times more likely to have at least a 50% reduction in seizures compared to those not on the diet, indicating its strong efficacy as a treatment option.
Article Abstract
Background: The ketogenic diet is a non-pharmacologic treatment option for children with drug-resistant epilepsy. This systematic review and meta-analysis aimed to assess the efficacy of the ketogenic diet on seizures frequency in children.
Methods: We reviewed the literature using Cochrane, EMBASE, MEDLINE, and highly qualified journals.Randomized controlled trials were chosen to investigate the seizures-free regime or at least 50% seizures reduction after three months from the starting of the ketogenic diet or earlier. We have selected articles from January 2011 to January 2020.Eight articles were eligible. The data show a significant reduction in seizure frequency in the dietary treatment pediatric population. The rate of a seizures-free regime or at least 50% seizures reduction was 48.31% of patients in the intervention group.
Results: Our overall meta-analysis underlined the significant efficacy. The KD group is 5.6 times more likely than the control group to have a 50% reduction of seizures after three months of the diet or earlier.QUADAS and AMSTAR assessments showed a low risk of bias and adequate accuracy.
Conclusion: The results show that the KD reduces seizure frequency in children with drug-refractory epilepsy. KD is an effective treatment option for children and adolescents with refractory epilepsy.
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| http://dx.doi.org/10.1080/14737175.2022.2030220 | DOI Listing |
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