AI Article Synopsis
- Multiple sclerosis (MS) is an autoimmune disease that is treatable but not curable, with various medications available to help manage symptoms and reduce relapses.
- Treatment responses vary among patients, and some may experience significant side effects, prompting research into alternative therapies like vitamin D.
- The review highlights the similarities between the underlying mechanisms of MS and experimental autoimmune encephalomyelitis, discussing vitamin D's potential benefits and the importance of administration methods and timing for patients with MS.
Article Abstract
Multiple sclerosis is an autoimmune treatable but not curable disease. There are a multiplicity of medications for multiple sclerosis therapy, including a class entitled disease-modifying drugs that are mainly indicated to reduce the number and severity of disease relapses. Not all patients respond well to these therapies, and minor to severe adverse effects have been reported. Vitamin D, called sunshine vitamin, is being studied as a possible light at the end of the tunnel. In this review, we recapitulated the similar immunopathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis, the immunomodulatory and neuroprotective potential of vitamin D and the state-of-art concerning its supplementation to multiple sclerosis patients. Finally, based on our and other groups' experimental findings, we analyzed the need to consider the relevance of the route and the different time-point administration aspects for a more rational indication of this vitamin to multiple sclerosis patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848597 | PMC |
| http://dx.doi.org/10.4103/1673-5374.335139 | DOI Listing |
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