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Antimicrobial activity of dimeric acylphloroglucinols isolated from southern Brazilian species against to resistant bacterial. | LitMetric

Antimicrobial activity of dimeric acylphloroglucinols isolated from southern Brazilian species against to resistant bacterial.

Nat Prod Res

Programa de Pós Graduação em Biologia Celular e Molecular Aplicada as Ciências Farmacêuticas (PPGBioSaúde), Universidade Luterana do Brasil (ULBRA), Canoas, RS, Brazil.

Published: December 2022

AI Article Synopsis

Article Abstract

The hexanic extracts of , , and , and three isolated dimeric acylphloroglucinols (uliginosin B, japonicine A and hyperbrasilol B) were assayed for their antimicrobial activity against some Gram-positive and Gram-negative bacteria (including resistant strains). These extracts were assayed using the disc diffusion test, and the results indicated that the tested species did non exhibit activity on the Gram-negative strains. Subsequently, the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were measured using the broth dilution technique adopted to macrodillution. The most susceptible strains were the MRSA and the MLSb. Regarding these pathogens, the better MIC values were obtained with the extracts from and . The acylphloroglucinols uliginosin B and hyperbrasilol B presented the lowest MIC values against , , MRSA and MLSb resistance.

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Source
http://dx.doi.org/10.1080/14786419.2022.2038596DOI Listing

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