Synthesis of aromatic lactone analogues of Lipoxin A4.

Objective: Synthesis of novel aromatic Lipoxin A4 lactone analogues.

Results: Novel para-substituted aromatic lactone analogues of Lipoxin A4 have been synthesized in a convergent manner with six steps in the longest linear sequence in 12-13% yields, employing 2-deoxy-D-ribose as a chiral pool starting material and the classical E-selective Wittig olefination.