Before you know it, you are on opposite sides of the fence: doctor and patient. That is how it feels when you hear that a disciplinary complaint has been made against you. But most complainants are not interested in this: they mainly want to be heard and, often, to see their complaint acted upon. Two mechanisms can explain why, as a doctor, it still feels like an attack. Complaint procedures often have the character of a court case. In that case, you are almost automatically on opposite sides. In addition, a complainant's request for clarification, or the need to be taken seriously, can escalate if an adequate response is not forthcoming. A more open response aimed at listening, repairing any damage and restoring the mutual relationship, can prevent escalation and thus also the passage to formal procedures. Such an open response is not always easy. Initiatives such as peer support can help here.
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Sci Rep
January 2025
Institute of Geomechanics, Chinese Academy of Geological Sciences, Beijing, 100081, China.
Loess is extensively developed on both sides of the Longwu River, a tributary of the Yellow River, Tongren County, Qinghai Province. The engineering geological characteristics are complex, and landslide disasters are highly developed. Based on field geological surveys and physical property analysis of the loess in this area, this study analyzes the influence of water content, consolidation pressure, and soil disturbance on the dynamic characteristics of loess using GDS dynamic triaxial tests.
View Article and Find Full Text PDFInt Immunol
January 2025
Department of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Photodynamic therapy (PDT), a local cancer treatment using photosensitizers, has been reported to enhance antitumor immune responses by inducing immunogenic cell death. Although several studies have demonstrated the synergistic antitumor effects of PDT and immune checkpoint blockage (ICB), the detailed underlying mechanisms remain poorly understood. In this study, we investigated the immunological effects of PDT with talaporfin (Tal-PDT), a clinically approved photosensitizer, using bilateral tumor-bearing mouse models.
View Article and Find Full Text PDFBioinspir Biomim
January 2025
Mathematics and Statistics, College of New Jersey, 2000 Pennington Road, Ewing, New Jersey, 08628, UNITED STATES.
Tomopterids are mesmerizing holopelagic swimmers. They use two modes of locomotion simultaneously: drag-based metachronal paddling and bodily undulation.has two rows of flexible legs (parapodia) positioned on opposite sides of its body.
View Article and Find Full Text PDFJ Struct Biol
January 2025
Department of Biochemical Engineering, University College London, London, United Kingdom. Electronic address:
Despite sharing ∼ 43 % sequence identity and structurally similar individual domains, botulinum neurotoxin (BoNT) serotypes A and E have differences in their properties and domain positioning. BoNT/E has a faster onset of action than BoNT/A. This difference is proposed to be due to conformational differences between BoNT/E and the other BoNT serotypes.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Departament de Ciència de Materials i Química Física & Institut de Química Teòrica i Computacional (IQTCUB), Universitat de Barcelona, c/Martí i Franquès 1-11, Barcelona 08028, Spain.
The oxygen reduction reaction (ORR) stands as a pivotal process in electrochemistry, finding applications in various energy conversion technologies such as fuel cells, metal-air batteries, and chlor-alkali electrolyzers. Hereby, a comprehensive density functional theory (DFT) investigation is presented into the proposed conventional and unconventional ORR mechanisms using single-atom catalysts (SACs) supported on nitrogen-doped graphene (NG) as model systems. Several reaction intermediates have been identified that appear to be more stable than the ones postulated in the conventional mechanism, which follows the *OOH, *O, and *OH intermediates.
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