AI Article Synopsis
- The review focuses on updating the understanding of primary central nervous system vasculitis (PCNSV), including its assessment, diagnosis, complications, and treatments.
- Recent advancements in neuroimaging and testing are enhancing diagnostic accuracy, helping differentiate between inflammatory and non-inflammatory conditions.
- While treatment approaches remain largely empirical, emerging evidence shows a more favorable prognosis and response to therapy for various clinical subsets of PCNSV.
Article Abstract
Purpose Of Review: The aim of this review is to provide a comprehensive update on the clinical assessment, diagnosis, complications, and treatment of primary central nervous system vasculitis (PCNSV).
Recent Findings: The developments in neuroimaging, molecular testing, and cerebral biopsy have enhanced clinical assessment and decision making, providing novel insights to prevent misdiagnosis increasing diagnostic certainty. Advances in imaging techniques visualizing the wall of intracranial vessels have improved the possibility to distinguish inflammatory from non-inflammatory vascular lesions. Large recent studies have revealed a more varied histopathological pictures and disclosed an association with amyloid angiopathy. Unfortunately, therapy remains largely empiric. PCNSV is a heterogeneous group of disorders encompassing different clinical subsets that may differ in terms of prognosis and therapy. Recent evidence has described a more benign course, with good response to therapy. New diagnostic techniques will play soon a pivotal role in the appropriate diagnosis and prompt management of PCNSV.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056593 | PMC |
| http://dx.doi.org/10.1007/s11910-022-01172-z | DOI Listing |
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