Classifying MR images based on their contrast mechanism can be useful in image segmentation where additional information from different contrast mechanisms can improve intensity-based segmentation and help separate the class distributions. In addition, automated processing of image type can be beneficial in archive management, image retrieval, and staff training. Different clinics and scanners have their own image labeling scheme, resulting in ambiguity when sorting images. Manual sorting of thousands of images would be a laborious task and prone to error. In this work, we used the power of transfer learning to modify pretrained residual convolution neural networks to classify MRI images based on their contrast mechanisms. Training and validation were performed on a total of 5169 images belonging to 10 different classes and from different MRI vendors and field strengths. Time for training and validation was 36 min. Testing was performed on a different data set with 2474 images. Percentage of correctly classified images (accuracy) was 99.76%. (A deeper version of the residual network was trained for 103 min and showed slightly lower accuracy of 99.68%.) In consideration of model deployment in the real world, performance on a single CPU computer was compared with GPU implementation. Highly accurate classification, training, and testing can be achieved without use of a GPU in a relatively short training time, through proper choice of a convolutional neural network and hyperparameters, making it feasible to improve accuracy by repeated training with cumulative training sets. Techniques to improve accuracy further are discussed and demonstrated. Derived heatmaps indicate areas of image used in decision making and correspond well with expert human perception. The methods used can be easily extended to other classification tasks with minimal changes.
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http://dx.doi.org/10.1007/s10278-022-00583-1 | DOI Listing |
J Pathol
January 2025
The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.
Spatial transcriptomics (ST) offers enormous potential to decipher the biological and pathological heterogeneity in precious archival cancer tissues. Traditionally, these tissues have rarely been used and only examined at a low throughput, most commonly by histopathological staining. ST adds thousands of times as many molecular features to histopathological images, but critical technical issues and limitations require more assessment of how ST performs on fixed archival tissues.
View Article and Find Full Text PDFMagn Reson Med
January 2025
F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA.
Purpose: We hypothesized that radiation-induced tubulointerstitial changes in the kidney can be assessed using MRI-based T relaxation time measurements.
Methods: We performed MRI, histology, and serum biochemistry in two mouse models of radiation nephropathy: one involving external beam radiotherapy and the other using internal irradiation with an α-particle-emitting actinium-225 radiolabeled antibody. We compared the mean T values of different renal compartments between control and external beam radiotherapy or α-particle-emitting actinium-225 radiolabeled antibody-treated groups and between the two radiation-treated groups using a Wilcoxon rank-sum test.
Acta Radiol
January 2025
Department of Medical Imaging, Dalin Tzu-Chi Hospital, Chiayi, Taiwan.
Background: The wide variability in thresholds on computed tomography (CT) perfusion parametric maps has led to controversy in the stroke imaging community about the most accurate measurement of core infarction.
Purpose: To investigate the feasibility of using U-Net to perform infarct core segmentation in CT perfusion imaging.
Material And Methods: CT perfusion parametric maps were the input of U-Net, while the ground truth segmentation was determined based on diffusion-weighted imaging (DWI).
ACS Appl Mater Interfaces
January 2025
Beijing Key Laboratory of Construction-Tailorable Advanced Functional Materials and Green Applications Experimental Center of Advanced Materials, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, China.
Metal halide perovskites (MHPs) are promising materials for radiation detection. Compared with polycrystalline films, single crystals (SCs) have lower defect density, higher carrier mobility, and lifetime. However, the direct synthesis of MHP SCs for large-area flat panel imaging detectors remains challenging.
View Article and Find Full Text PDFArterioscler Thromb Vasc Biol
January 2025
School of Life Science, Nantong Laboratory of Development and Diseases and Co-Innovation Center of Neuroregeneration, Nantong University, China.
Background: Sprouting blood vessels, reaching the aimed location, and establishing the proper connections are vital for building vascular networks. Such biological processes are subject to precise molecular regulation. So far, the mechanistic insights into understanding how blood vessels grow to the correct position are limited.
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