Herein, we have successfully synthesized a novel CS-PDMA/AuNPs nanocomposite based on -chitosan containing poly(2,5-dimethoxyaniline) capped gold nanoparticle synthesis is reported. The AuNPs were synthesized using the green method without using any harmful chemicals, reducing and stabilizing agents to generate AuNPs, is not needed because these roles are played by CS. The synthesized CS-PDMA/AuNPs nanocomposite were characterized by UV-Vis, FT-IR, XRD, SEM, and TEM analysis. The polydispersed CS-PDMA/AuNPs nanocomposite was observed approximately 25 nm. Furthermore, CS-PDMA/AuNPs nanocomposite was showed significant antibacterial activity against and . The CS-PDMA/AuNPs nanocomposite showed strong antioxidant activity by inhibiting the DPPH radicals. In addition, the cytotoxicity of CS-PDMA/AuNPs nanocomposite was tested in HeLa cells and found to be high toxicity than CS-PDMA. This work suggests that green synthesized CS-PDMA/AuNPs nanocomposite may be utilized as an effective antibacterial, antioxidant, and anticancer activity.[Figure: see text]Research highlightsnCS-PDMA capped gold nanoparticles (nCS-PDMA/AuNPs) were prepared.Physical characterization of nCS-PDMA/AuNPs by UV-vis, FTIR, XRD, SEM, and TEM.nCS-PDMA/AuNPs displayed promising inhibitory activity against both bacteria.nCS-PDMA/AuNPs showed significant DPPH radical scavenging activities.nCS-PDMA/AuNPs showed an excellent anticancer activity against HeLa cells.
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