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A phase 2 trial of avelumab in men with aggressive-variant or neuroendocrine prostate cancer.
Prostate Cancer Prostatic Dis
April 2022
Duke Cancer Institute Center for Prostate and Urologic Cancers, Department of Medicine Division of Medical Oncology, Duke University, Durham, NC, USA.
Background: Men with progressive neuroendocrine or aggressive-variant metastatic prostate cancer (NEPC/AVPC) have a poor prognosis and limited treatment options, and immunotherapy has not been tested in such patients.
Methods: We conducted an open label single center phase 2 trial (NCT03179410) of men with progressive NEPC/AVPC either defined by histology or AVPC criteria. Avelumab (10 mg/kg every 2 weeks) was administered until progression or unacceptable toxicity.
Primary gastric choriocarcinoma - a rare and aggressive tumor with multilineage differentiation: A case report.
World J Clin Cases
July 2019
Department of Pathology, University of Medicine, Pharmacy, Sciences and Technology, Targu Mures 530149, Romania.
Background: Primary choriocarcinoma of the stomach (PCCS) is a rare tumor, with fewer than 60 cases published in the English-language literature up to December 2018. In this paper, we present the complex immunoprofile of one PCCS and a hypothesis regarding its histogenesis.
Case Summary: A 66-year-old previously healthy male underwent an emergency palliative gastrectomy for a gastric obstructive tumor.
Aggressive-Variant Microsatellite-Stable POLE Mutant Prostate Cancer With High Mutation Burden and Durable Response to Immune Checkpoint Inhibitor Therapy.
JCO Precis Oncol
November 2018
Lisa Lee, Elizabeth Genega, Dallas Reed, and Paul Mathew, Tufts Medical Center, Boston; Siraj Ali and Ethan Sokol, Foundation Medicine, Cambridge, MA.
Colorectal micropapillary carcinomas are associated with poor prognosis and enriched in markers of stem cells.
Mod Pathol
August 2013
Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Colorectal micropapillary carcinoma has recently been reported as an aggressive variant of adenocarcinoma with a high incidence of lymph node metastasis, but has not been well investigated in terms of survival analysis. This study analyzed the clinicopathological characteristics, including survival data, of the patients with micropapillary carcinoma. We hypothesized that the aggressive features of micropapillary carcinoma might be related to the presence of more tumor cells with stem cell phenotype in colorectal cancer.
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