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Microfluidic-Enabled Self-Directed Hydrogel Microspheres for Multiplexed MicroRNA Assays.
Anal Chem
January 2025
MOE Key Laboratory of Geriatric Nutrition and Health, Department of Bioengineering, Beijing Technology and Business University, Beijing 100048, China.
Multiplexed microRNA (miRNA) detection has proven valuable in disease diagnosis; yet, the development of advanced tools for their analysis remains a subject of broad interest. Here, we propose a novel single-particle method for multiplexed miRNA detection using self-directed hydrogel microspheres, which feature supersegmented compartments for loading analyte probes and an air-encapsulated region that grants the microsphere a unique preferred posture in aqueous solutions. By exploiting microfluidic technology, we can widely adjust the size of the microspheres and the number of compartments can be widely adjusted.
View Article and Find Full Text PDFEngineering Covalent Aptamer Chimeras for Enhanced Autophagic Degradation of Membrane Proteins.
Angew Chem Int Ed Engl
January 2025
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China.
Targeted degradation of membrane proteins represents an attractive strategy for eliminating pathogenesis-related proteins. Aptamer-based chimeras hold great promise as membrane protein degraders, however, their degradation efficacy is often hindered by the limited structural stability and the risk of off-target effects due to the non-covalent interaction with target proteins. We here report the first design of a covalent aptamer-based autophagosome-tethering chimera (CApTEC) for the enhanced autophagic degradation of cell-surface proteins, including transferrin receptor 1 (TfR1) and nucleolin (NCL).
View Article and Find Full Text PDFDroplets in open microfluidics: generation, manipulation, and application in cell analysis.
Lab Chip
January 2025
Department of Chemistry, Beijing Key Laboratory of Microanalytical Methods and Instrumentation, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, P. R. China.
Open droplet microfluidics is an emerging technology that generates, manipulates, and analyzes droplets in open configuration systems. Droplets function as miniaturized reactors for high-throughput analysis due to their compartmentalization and parallelization, while openness enables addressing and accessing the targeted contents. The convergence of two technologies facilitates the localization and intricate manipulation of droplets using external tools, showing great potential in large-scale chemical and biological applications, particularly in cell analysis.
View Article and Find Full Text PDFNew Benzofuran-Pyrazole-Based Compounds as Promising Antimicrobial Agents: Design, Synthesis, DNA Gyrase B Inhibition, and In Silico Studies.
Pharmaceuticals (Basel)
December 2024
Department of Chemistry, Prairie View A&M University, Prairie View, TX 77446, USA.
Background/objectives: The alarming rise in antibiotic resistance necessitates the discovery of novel antimicrobial agents. This study aims to design, synthesize, and evaluate new benzofuran-pyrazole-based compounds for their antimicrobial, antioxidant, and anti-inflammatory properties.
Methods: New benzofuran-pyrazole hybrid molecules were synthesized using the Vilsmeier-Haach reaction and other chemical processes.
Shortwave Infrared Hyperspectral Imaging to Detect Contaminants in the U.S. Food Supply.
Appl Spectrosc
December 2024
The MITRE Corporation, McLean, Virginia, USA.
Article Synopsis
- The FDA monitors food safety through inspections and laboratory tests, focusing on detecting foreign elements in food samples for better regulatory decisions.
- Researchers are investigating shortwave infrared (SWIR) hyperspectral imaging to efficiently identify filth elements in various food types, including different beetle species.
- The study found that SWIR imaging could successfully detect whole beetles and small fragments in 95% of samples, suggesting it could enhance FDA's analytical capabilities and food safety measures.
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