AI Article Synopsis
- Infectious diseases, particularly tuberculosis, pose ongoing health challenges, with resistance being a major issue in affected patients.
- Novel anti-infective agents, especially membrane-active compounds, show promise in targeting bacteria and overcoming resistance due to their ability to affect essential membrane components.
- The review highlights advancements in developing these compounds, their potential against dormant bacteria, and discusses both their benefits and limitations, aiming to guide future research for effective tuberculosis treatments.
Article Abstract
Infectious diseases remain significant health concerns worldwide, and resistance is particularly common in patients with tuberculosis caused by . The development of anti-infectives with novel modes of action may help overcome resistance. In this regard, membrane-active agents, which modulate membrane components essential for the survival of pathogens, present attractive antimicrobial agents. Key advantages of membrane-active compounds include their ability to target slow-growing or dormant bacteria and their favorable pharmacokinetics. Here, we comprehensively review recent advances in the development of membrane-active chemotypes that target mycobacterial membranes and discuss clinically relevant membrane-active antibacterial agents that have shown promise in counteracting bacterial infections. We discuss the relationship between the membrane properties and the synthetic requirements within the chemical scaffold, as well as the limitations of current membrane-active chemotypes. This review will lay the chemical groundwork for the development of membrane-active antituberculosis agents and will foster the discovery of more effective antitubercular agents.
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| http://dx.doi.org/10.1021/acs.jmedchem.1c01870 | DOI Listing |
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