Correction for 'Recent advances in fluorescent probes for lipid droplets' by Yanyan Zhao , , 2022, , 1495-1509, DOI: 10.1039/D1CC05717K.
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Technological advances in clinical individualized medication for cancer therapy: from genes to whole organism.
Per Med
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Department of Clinical Pharmacy, Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Efforts have been made to leverage technology to accurately identify tumor characteristics and predict how each cancer patient may respond to medications. This involves collecting data from various sources such as genomic data, histological information, functional drug profiling, and drug metabolism using techniques like polymerase chain reaction, sanger sequencing, next-generation sequencing, fluorescence in situ hybridization, immunohistochemistry staining, patient-derived tumor xenograft models, patient-derived organoid models, and therapeutic drug monitoring. The utilization of diverse detection technologies in clinical practice has made "individualized treatment" possible, but the desired level of accuracy has not been fully attained yet.
View Article and Find Full Text PDFVisualizing Endoplasmic Reticulum Stress and Autophagy in Alzheimer's Model Cells by a Peroxynitrite-Responsive AIEgen Fluorescent Probe.
ACS Chem Neurosci
January 2025
Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Endoplasmic reticulum (ER) stress and autophagy (ER-phagy) occurring in nerve cells are crucial physiological processes closely associated with Alzheimer's disease (AD). Visualizing the two processes is paramount to advance our understanding of AD pathologies. Among the biomarkers identified, peroxynitrite (ONOO) emerges as a key molecule in the initiation and aggravation of ER stress and ER-phagy, highlighting its significance in the underlying mechanisms of the two processes.
View Article and Find Full Text PDFDeep learning-based prediction of HER2 status and trastuzumab treatment efficacy of gastric adenocarcinoma based on morphological features.
J Transl Med
January 2025
Department of Pathology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, 350014, China.
Background: First-line treatment for advanced gastric adenocarcinoma (GAC) with human epidermal growth factor receptor 2 (HER2) is trastuzumab combined with chemotherapy. In clinical practice, HER2 positivity is identified through immunohistochemistry (IHC) or fluorescence in situ hybridization (FISH), whereas deep learning (DL) can predict HER2 status based on tumor histopathological features. However, it remains uncertain whether these deep learning-derived features can predict the efficacy of anti-HER2 therapy.
View Article and Find Full Text PDFThe combination of hyaluronic acids and collagen boosts human Achilles tendon-derived cell escape from inflammation and matrix remodeling in vitro.
Inflamm Res
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Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, 66100, Chieti, Italy.
Objective: This study explores whether hyaluronic acid (HA) of different molecular weights and collagen, given their role in tendon extracellular matrix maintenance, have a synergistic effect on human tendon-derived cells, with the aim to improve the treatment of tendinopathy.
Material: Human monocytes (CRL-9855™) and primary Achilles tendon-derived cells.
Treatment: The collagen/HA ratio was based on the formulation of the commercial food supplement TendoGenIAL™.
Detachment of the Intersegmental Plane in Robotic Left Hepatectomy Using Indocyanine Green Fluorescent Imaging (with Video).
Ann Surg Oncol
January 2025
Center for Liver and Pancreatobiliary Cancer, National Cancer Center, Goyang-si, Korea.
Background: Anatomical liver resection has been altered by a deeper understanding of the internal structure of the liver, highlighting the importance of the intersegmental plane, a region lacking Glissonean branches. These insights have enabled a novel surgical technique focused on the precise detachment of the intersegmental plane, supported by indocyanine green (ICG) fluorescent imaging and robotic platforms, enhancing the precision and safety of liver resection.
Methods: This study involved four patients who underwent robotic left hepatectomy using the Da Vinci Xi system.
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