Current soft robotic arms commonly follow traditional - i.e., hard - robot design conventions. Omnidirectional soft arms most commonly consist of segments that contain three parallel longitudinal actuators, or actuator groups, of which one or two are activated to induce bending. This design uses the minimum number of actuators required for omnidirectional bending, which is consistent with traditional robot design but unnecessarily constrains the soft arm design space. The cephalopods that frequently inspire soft robot arms have tens of bundles of longitudinal muscle fibers, and these bundles are distributed around the limb circumference rather than grouped. This article analyzes fluid-driven soft arm architectures with up to 12 actuators, which mimic the redundant and distributed nature of cephalopod arms and tentacles. Over-constraints (activating more than two actuators) were considered, which are possible because soft robots - unlike traditional robots - can tolerate conflicting constraints without jamming. A previously-developed generalizable model was used to simulate design performance, and a subset of the examined architectures were constructed and tested. Many-actuator soft arms achieved high strokes under equivalent load without sacrificing no-load reach and were able to execute near constant-curvature turns with a simple actuation pattern. The framework introduced here also enables cross section variations that are not possible with minimalist designs.
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http://dx.doi.org/10.1088/1748-3190/ac52e5 | DOI Listing |
J Orthop Surg Res
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Department of Orthopaedics, the 960th Hospital of PLA, 25 shifan Road, Tianqiao District, Jinan, Shandong, 250031, China.
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Department of Pathology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China.
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January 2025
Computational Biophysics and Imaging Group, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Vasculature of the small bowel mucosa, with a significant role in nutrient absorption and gut homeostasis, has been suggested to undergo remodeling in various gastrointestinal disorders, including celiac disease. However, due to its spatial organization within the mucosa, conventional 2D histological methods are of limited value in studying the intestinal vasculature reliably. X-ray microtomography (micro-CT) is a promising tool for soft tissue imaging, as it enables digital 3D reconstruction of various tissue samples, including endoscopically obtained small-bowel mucosal biopsies.
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Lab Invest
January 2025
Interdisciplinary Oncology, University of British Columbia, Vancouver, Canada; Molecular and Advanced Pathology Core, University of British Columbia, Vancouver, Canada; Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada. Electronic address:
Immunotherapy has emerged as a new treatment modality in some soft tissue sarcomas, particularly for tumors associated with tertiary lymphoid structures (TLS). These structures are functional lymphoid aggregates, and their presence is indicative of an active anticancer immune response in the tumor microenvironment. The assessment of TLS as a predictive biomarker at scale on patient specimens remains challenging.
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