Three novel strains of Gram-stain-negative, obligately anaerobic, spore-forming straight or slightly curved rods with pointed ends occurring singly or in pairs were isolated from the faeces of healthy human children. The strains were characterized by mesophilic fermentative metabolism and production of acetate, ethanol and H as the end metabolic products. Strains ASD3451 and ASD5720 were motile, fermented lactose and raffinose, and weakly fermented maltose. Strain ASD4241 was non-motile and did not ferment the carbohydrates listed above but fermented starch. Strains ASD3451 and ASD5720 shared average nucleotide identity higher than 98.5 % with each other, while ASD4241 had only 88.5-89 % identity to them. Based on phylogenetic and chemotaxonomic analyses, we propose gen. nov., sp. nov. (ASD5720=JCM 34353=VKM B-3497) and sp. nov. (ASD4241=JCM 34351=VKM B-3498) within the family .
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1099/ijsem.0.005222 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Selective Colocalization of GHSR and GLP-1R in a Subset of Hypothalamic Neurons and Their Functional Interaction.
Endocrinology
November 2024
Laboratory of Neurophysiology, Multidisciplinary Institute of Cell Biology [IMBICE; Argentine Research Council (CONICET); Scientific Research Commission, Province of Buenos Aires (CIC-PBA); National University of La Plata], B1906APO La Plata, Buenos Aires, Argentina.
The GH secretagogue receptor (GHSR) and the glucagon-like peptide-1 receptor (GLP-1R) are G protein-coupled receptors with critical, yet opposite, roles in regulating energy balance. Interestingly, these receptors are expressed in overlapping brain regions. However, the extent to which they target the same neurons and engage in molecular crosstalk remains unclear.
View Article and Find Full Text PDFAssessing the antibiofilm activity of flavonol esters against PAO1 biofilm: an , molecular docking, and molecular dynamics study.
J Biomol Struct Dyn
February 2025
Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, India.
is one of the opportunistic pathogens that may cause serious health problems and can produce several virulence factors, which are responsible for various infections, particularly in immunocompromised patients. They are responsible for producing infections on indwelling medical devices by attaching on to them and forming a biofilm. Antibiofilm, antivirulence, and gene expression studies of biofilm treated with esters of flavonols were evaluated.
View Article and Find Full Text PDFInvestigation of ritonavir analogs antiretroviral natural compounds against SARS-CoV-2 envelope protein.
J Biomol Struct Dyn
February 2025
Department of Physics, DDU Gorakhpur University, Gorakhpur, Uttar Pradesh, India.
Since the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported from Wuhan, China, there has been a surge in scientific research to find a permanent cure for the disease. The main challenge in effective drug discovery is the continuously mutating nature of the SARS-CoV-2 virus. Thus, we have used the I-TASSER modeling to predict the structure of the SARS-CoV-2 viral envelope protein followed by combinatorial computational assessment to predict its putative potential small molecule inhibitors.
View Article and Find Full Text PDFInvestigation of the impact of R273H and R273C mutations on the DNA binding domain of P53 protein through molecular dynamic simulation.
J Biomol Struct Dyn
February 2025
Laboratory of Integrative Genomics, Department of Integrative Biology, School of Bio Sciences and Technology, Vellore Institute of Technology (VIT), Vellore, India.
The P53 protein, a cancer-associated transcriptional factor and tumor suppressor, houses a Zn ion in its DNA-binding domain (DBD), essential for sequence-specific DNA binding. However, common mutations at position 273, specifically from Arginine to Histidine and Cysteine, lead to a loss of function as a tumor suppressor, also called DNA contact mutations. The mutant (MT) P53 structure cannot stabilize DNA due to inadequate interaction.
View Article and Find Full Text PDFAudiology Through a Psychologically Informed Practice Lens.
Ear Hear
November 2024
National Acoustic Laboratories, Sydney, Australia.
Psychologically informed practice is a structural framework originating in physiotherapy, that aids clinicians to identify, consider, and address the psychological factors related to chronic conditions and their management. Hearing loss is a chronic condition associated with a variety of psychosocial impacts, and psychological factors are known to heavily influence the engagement, adherence, and success of hearing rehabilitation. This framework could provide a structured method to manage these factors by using evidence-based psychological theory and applications.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!