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1613-682918132022AprSmall (Weinheim an der Bergstrasse, Germany)SmallHarnessing the Therapeutic Potential of Extracellular Vesicles for Biomedical Applications Using Multifunctional Magnetic Nanomaterials.e2104783e210478310.1002/smll.202104783Extracellular vesicles (e.g., exosomes) carrying various biomolecules (e.g., proteins, lipids, and nucleic acids) have rapidly emerged as promising platforms for many biomedical applications. Despite their enormous potential, their heterogeneity in surfaces and sizes, the high complexity of cargo biomolecules, and the inefficient uptake by recipient cells remain critical barriers for their theranostic applications. To address these critical issues, multifunctional nanomaterials, such as magnetic nanomaterials, with their tunable physical, chemical, and biological properties, may play crucial roles in next-generation extracellular vesicles (EV)-based disease diagnosis, drug delivery, tissue engineering, and regenerative medicine. As such, one aims to provide cutting-edge knowledge pertaining to magnetic nanomaterials-facilitated isolation, detection, and delivery of extracellular vesicles and their associated biomolecules. By engaging the fields of extracellular vesicles and magnetic nanomaterials, it is envisioned that their properties can be effectively combined for optimal outcomes in biomedical applications.© 2022 Wiley-VCH GmbH.YangLetaoL0000-0002-0572-9787Department of Chemistry and Chemical Biology, Rutgers-the State University of New Jersey, 123 Bevier Road, Piscataway, NJ, 08854, USA.PatelKapil DKD0000-0002-0393-9166Department of Materials Science and Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.RathnamChristopherC0000-0003-3111-4687Department of Chemistry and Chemical Biology, Rutgers-the State University of New Jersey, 123 Bevier Road, Piscataway, NJ, 08854, USA.ThangamRamarRDepartment of Materials Science and Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.HouYannanY0000-0002-5499-6865Department of Chemistry and Chemical Biology, Rutgers-the State University of New Jersey, 123 Bevier Road, Piscataway, NJ, 08854, USA.KangHeeminH0000-0003-1359-2810Department of Materials Science and Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.LeeKi-BumKB0000-0002-8164-0047Department of Chemistry and Chemical Biology, Rutgers-the State University of New Jersey, 123 Bevier Road, Piscataway, NJ, 08854, USA.engR21AR071101NHNIH HHSUnited States1R01DC016612NHNIH HHSUnited States3R01DC016612-04S2NHNIH HHSUnited StatesR21 AR071101ARNIAMS NIH HHSUnited States3R01DC016612-01S1NHNIH HHSUnited States5R01DC016612-02S1NHNIH HHSUnited StatesR01 DC016612DCNIDCD NIH HHSUnited States3R01DC016612-04S1NHNIH HHSUnited StatesJournal ArticleReviewResearch Support, Non-U.S. Gov'tResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, Non-P.H.S.20220208
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