Objective: The auditory nerve overlapped waveform response (ANOW), a new measure that can be recorded non-invasively from humans, holds promise for providing more accurate assessment of low frequency hearing thresholds than currently used objective measures. This research aims to investigate the robustness and the nature of the ANOW response in humans.

Design: Repeated within-session recordings of the ANOW response using low-frequency Tone Bursts (TBs) were obtained at multiple stimulus levels. ANOW's absolute amplitude and phase locking value (PLV) measures were analysed to obtain normative data and to test the reliability of the ANOW response.

Study Sample: Thirteen normal hearing adults within the age range of 25 to 40 years.

Results: ANOW response was obtained to both 250 Hz and 500 Hz TBs and was traced down to 30-40 dB nHL. ANOW response showed significantly higher amplitude and stronger phase locking using 250 Hz TB compared to 500 Hz TB. High degree of test retest reliability of the ANOW response was found using 250 Hz TB at presentation levels higher than 40 dB nHL.

Conclusions: ANOW response is recordable noninvasively using low-frequency TBs and shows higher robustness as the stimulus frequency decreases.

Download full-text PDF

Source
http://dx.doi.org/10.1080/14992027.2021.2024283DOI Listing

Publication Analysis

Top Keywords

anow response
24
auditory nerve
8
response
8
normal hearing
8
hearing adults
8
anow
8
phase locking
8
reliability anow
8
response 250 hz
8
nerve phase-locked
4

Similar Publications

Objective: The auditory nerve overlapped waveform response (ANOW), a new measure that can be recorded non-invasively from humans, holds promise for providing more accurate assessment of low frequency hearing thresholds than currently used objective measures. This research aims to investigate the robustness and the nature of the ANOW response in humans.

Design: Repeated within-session recordings of the ANOW response using low-frequency Tone Bursts (TBs) were obtained at multiple stimulus levels.

View Article and Find Full Text PDF

Our Current Dietary Reference Intakes for Vitamin A-Now 20 Years Old.

Curr Dev Nutr

October 2020

USDA/Agricultural Research Service Children's Nutrition Research Center/Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.

The DRI values for vitamin A were last reviewed and defined in 2001. At the time, there was very sparse data that could be used to set the DRI values for pregnancy, lactation, and infancy. In the subsequent 20 y since the last formal review, a number of findings relevant to the adequacy indicator of visual dark adaptation in pregnancy, the usual vitamin A content of breast milk across lactation stages, and vitamin A metabolism in women and children have been published.

View Article and Find Full Text PDF

With changes to cochlear implant candidacy and improvements in surgical technique, there is a need for accurate intraoperative assessment of low-frequency hearing thresholds during cochlear implantation. In electrocochleography, onset compound action potentials (CAPs) typically allow estimation of auditory threshold for frequencies above 1 kHz, but they are less accurate at lower frequencies. Auditory nerve neurophonic (ANN) waveforms, on the other hand, may overcome this limitation by allowing phase-locked neural activity to be tracked during a prolonged low-frequency stimulus rather than just at its onset (Henry, 1995).

View Article and Find Full Text PDF
Article Synopsis
  • Electrocochleography (ECochG) has limitations in assessing low-frequency hearing loss related to Ménière's disease, as current techniques focus mainly on high-frequency measurements.
  • A new ECochG method using the Auditory Nerve Overlapped Waveform (ANOW) was tested on guinea pig ears to evaluate the effects of induced endolymphatic hydrops.
  • The study found that ANOW amplitudes significantly decreased with hydropic manipulations, indicating it may effectively identify early dysfunctions in Ménière's disease before conventional methods show changes.
View Article and Find Full Text PDF

The auditory nerve overlapped waveform (ANOW) originates in the cochlear apex.

J Assoc Res Otolaryngol

June 2014

Department of Otolaryngology, Washington University School of Medicine, Box 8115, 660 South Euclid Avenue, St. Louis, MO, 63110, USA,

Measurements of cochlear function with compound action potentials (CAPs), auditory brainstem responses, and otoacoustic emissions work well with high-frequency sounds but are problematic at low frequencies. We have recently shown that the auditory nerve overlapped waveform (ANOW) can objectively quantify low-frequency (<1 kHz) auditory sensitivity, as thresholds for ANOW at low frequencies and for CAP at high frequencies relate similarly to single auditory nerve fiber thresholds. This favorable relationship, however, does not necessarily mean that ANOW originates from auditory nerve fibers innervating low-frequency regions of the cochlear apex.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!