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No sex-based differences in odds of starting or time to treatment of generalized myasthenia gravis: A single center cohort study.
Muscle Nerve
October 2024
Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Article Synopsis
- * A retrospective analysis of 179 gMG patients from the University of Calgary found that the likelihood of starting treatment and the time from diagnosis to treatment initiation did not differ between sexes when accounting for various factors.
- * The findings suggest that the differences in quality of life seen in females with gMG are not related to treatment initiation, indicating that further research should focus on exploring physician and patient preferences in treatment strategies.
[Various phenotypes of postpartum atypical hemolytic uremic syndrome: the role of genetic testing in determining prognosis. Case report].
Ter Arkh
August 2023
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology.
We report a case of atypical hemolytic uremic syndrome (aHUS) that occurred after childbirth in a patient with a history of numerous recurrent episodes of TMA with nephrotic proteinuria and impaired renal function. At 33 weeks of the first spontaneous pregnancy, proteinuria up to 0.8 g/l was first registered, at 38 weeks she was hospitalized with proteinuria, reaching a maximum of 13 g/l, she was delivered promptly, after which progressive thrombocytopenia was noted over the next few days (up to 44×10/l) and anemia and severe arterial hypertension, which could not be corrected by several groups of antihypertensive drugs.
View Article and Find Full Text PDFThe effect of complement C3 or C5 inhibition on geographic atrophy secondary to age-related macular degeneration: A living systematic review and meta-analysis.
Surv Ophthalmol
April 2024
Division of Ophthalmology, Department of Surgery, McMaster University, Hamilton, Ontario, Canada; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada. Electronic address:
Article Synopsis
- New therapies for geographic atrophy (GA) are now available, allowing for better management in clinical settings.
- A living systematic review found that inhibiting complement factors C3 and C5 may reduce the growth of GA over 12 and 24 months, with little difference in side effects compared to sham treatments.
- However, these treatments do not seem to improve visual acuity significantly and may lead to more ocular adverse effects and new cases of neovascular age-related macular degeneration.
Correction to: Comparative Effectiveness of Pegcetacoplan Versus Ravulizumab and Eculizumab in Complement Inhibitor-Naïve Patients with Paroxysmal Nocturnal Hemoglobinuria: A Matching-Adjusted Indirect Comparison.
Adv Ther
December 2023
Analysis Group, Inc., 111 Huntington Avenue, 14th Floor, Boston, MA, 02199, USA.
Impact of Cataract Surgery on Low Luminance Visual Acuity Deficit Measurements.
Ophthalmol Sci
September 2022
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.
Purpose: The impact of cataract surgery on low luminance visual acuity deficit (LLVAD) measurements was investigated by measuring the LLVAD before and after cataract surgery.
Design: Prospective, longitudinal study.
Participants: Patients undergoing cataract surgery.
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