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Microsensor systems for cell metabolism - from 2D culture to organ-on-chip (2019-2024).
Lab Chip
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Laboratory for Electrical Instrumentation and Embedded Systems, IMTEK - Department of Microsystems Engineering, University of Freiburg, Georges-Köhler-Allee 103, 79110 Freiburg, Germany.
Cell cultures, organs-on-chip and microphysiological systems become increasingly relevant as models, , in drug development, disease modelling, toxicology or cancer research. It has been underlined repeatedly that culture conditions and metabolic cues have a strong or even essential influence on the reproducibility and validity of such experiments but are often not appropriately measured or controlled. Here we review microsensor systems for cell metabolism for the continuous measurement of culture conditions in microfluidic and lab-on-chip platforms.
View Article and Find Full Text PDFReply to: "Comment on: Differences in Setting of Initial Dementia Diagnosis Among Fee-for-Service Medicare Beneficiaries".
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Department of Health Services, Policy, and Practice, Brown University School of Public Health, Providence, Rhode Island, USA.
Mechanisms of metabolism-coupled protein modifications.
Nat Chem Biol
January 2025
Boyce Thompson Institute, Cornell University, Ithaca, NY, USA.
Intricate coupling between metabolism and protein post-translational modifications (PTMs) has emerged as a fundamental aspect of cellular regulation. Recent studies demonstrate that protein modifications can originate from diverse metabolites, and that their regulation is closely tied to the cellular metabolic state. Here we explore recently uncovered PTMs, including the concept of 'modification of a modification', as well as associated feedback and feedforward regulatory mechanisms, in which modified proteins impact not only related metabolic pathways but also other signaling cascades affecting physiology and diseases.
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Department of Emergency Medicine, The Ohio State University, Columbus, Ohio, USA.
Comment on: Perioperative lifestyle and nutritional interventions' details reporting in bariatric surgery trials according to the TIDieR checklist: a cross-sectional study.
Surg Obes Relat Dis
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Pennington Biomedical Research Center at Louisiana State University, Baton Rouge, Louisiana; Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, Louisiana.
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