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Treating Diphenhydramine Overdose: A Literature Review of Currently Available Treatment Methods.
Toxics
May 2024
College of Graduate Studies, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA.
Article Synopsis
- From 2019 to 2020, antihistamines were involved in 15% of US drug overdose deaths, with diphenhydramine being the most common, and 3.6% of those deaths attributed solely to antihistamines.
- There is currently no specific antidote for diphenhydramine overdose, highlighting a gap in emergency treatment options.
- The review evaluates various treatments for antihistamine overdose, including traditional and newer methods, concluding that further research is necessary to identify the best therapeutic strategies.
Distribution of donepezil in postmortem casework.
J Forensic Leg Med
January 2024
NMS Labs, 200 Welsh Rd, Horsham, PA, USA.
Donepezil is one of the primary treatments options for patients suffering from Alzheimer's Disease. In a review of more than 2200 postmortem donepezil positive blood specimens, 76% of concentrations were higher than the proposed therapeutic range. Means and medians were similar between central blood specimens and peripheral specimens, indicating minimal postmortem redistribution.
View Article and Find Full Text PDFFollow-up of Clinical Symptoms and Blood Concentration in Donepezil Overdose.
Prim Care Companion CNS Disord
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Gifu Pharmaceutical University, Gifu, Japan.
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