The marine natural product ageladine A was synthesized by exploiting novel aza-BODIPY-type boron complexes that allowed the regioselective dibromination of the pyrrole unit, as confirmed by quantum chemical calculation (ωB97XD/TApr-cc-pVDZ). The parent tricycle was accessed by Suzuki-Miyaura cross-coupling employing Buchwald's precatalyst. The boron complex of ageladine A exhibited strong fluorescence that was greater than that of the natural product by a factor of ∼30 and that disappeared in the presence of 2-azido groups.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.1c04307 | DOI Listing |
Publication Analysis
Top Keywords
natural product
8
aza-bodipy route
4
route ageladine
4
ageladine marine
4
marine natural
4
product ageladine
4
ageladine synthesized
4
synthesized exploiting
4
exploiting novel
4
novel aza-bodipy-type
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!