Three new dibenzofurans, 2-hydroxy-3,4-dimethoxydibenzofuran (), 2,8-dihydroxy-3,4,9-trimethoxydibenzofuran () and 2-hydroxy-3,4,6,8-tetramethoxydibenzofuran (), together with three known dibenzofurans 1-hydroxy-2,3,4-trimethoxydibenzofuran (), 2-hydroxy-3,4,6-trimethoxydibenzofuran () and 1,6-dihydroxy-2,3,4-trimethoxydibenzofuran (), were isolated from the twigs and leaves of . Their structures were identified by the comprehensive analyses of the physicochemical properties and spectroscopic data (NMR and HR-ESI-MS). Compounds showed significant lipid-lowering activities, especially compound was stronger than simvastatin.
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http://dx.doi.org/10.1080/14786419.2022.2036146 | DOI Listing |
ACS Pharmacol Transl Sci
December 2024
University of Münster, Institute of Pharmaceutical and Medicinal Chemistry, Pharmacampus, Münster 48149, Germany.
The human protein kinase CK2 is a promising target for cancer treatment. Only two CK2 inhibitors have reached clinical trials until today. Among others, a dibenzofuran scaffold has emerged as highly prospective for the development of new CK2 inhibitors.
View Article and Find Full Text PDFSci Total Environ
December 2024
State Key Laboratory for Clean Energy Utilization, Institute for Thermal Power Engineering, Zhejiang University, Hangzhou 310027, China.
The "memory effect" of polychlorinated dibenzo-p-dioxin and dibenzofurans (PCDD/Fs) in wet scrubber (WS) has become a frequent negative phenomenon in waste incineration field. This work focuses on studying the major influence factors and pathways of memory effect of PCDD/Fs in WS from the aspects of PCDD/F carriers and operating conditions. The PCDD/F contents of fillings used for over three years is 0.
View Article and Find Full Text PDFEnviron Sci Technol
September 2024
State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai 200240, China.
Binding with proteins is a critical molecular initiating event through which environmental pollutants exert toxic effects in humans. Previous studies have been limited by the availability of three-dimensional (3D) protein structures and have focused on only a small set of environmental contaminants. Using the highly accurate 3D protein structure predicted by AlphaFold2, this study explored over 60 million interactions obtained through molecular docking between 20,503 human proteins and 1251 potential endocrine-disrupting chemicals.
View Article and Find Full Text PDFInorg Chem
September 2024
Fakultät Chemie und Lebensmittelchemie, Professur für Physikalische Organische Chemie, Technische Universität Dresden, Bergstrasse 66, 01069 Dresden, Germany.
Environ Sci Technol
August 2024
School of Energy and Power Engineering, Beihang University, Beijing 100191, PR China.
Polyhalogenated dibenzo--dioxins/dibenzofurans (PXDD/Fs) are commonly released into the environment as byproducts of combustion processes, accompanied by flue gases. Chlorinated (Cl) and brominated (Br) precursors play crucial roles in forming PXDD/Fs. However, the specific contributions of Cl-precursors and Br-precursors to PXDD/Fs formation have not been fully elucidated.
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