Mechanochemical transformations offer environmentally benign synthesis routes, whilst enhancing both the speed and selectivity of reactions. In this regard, mechanochemistry promises to transform the way in which chemistry is done in both academia and industry but is greatly hindered by a current lack of mechanistic understanding. The continued development and use of time-resolved in situ (TRIS) approaches to monitor mechanochemical reactions provides a new dimension to elucidate these fascinating transformations. We here discuss recent trends in method development that have pushed the boundaries of mechanochemical research. New features of mechanochemical reactions obtained by TRIS techniques are subsequently discussed, which sheds light on how different TRIS approaches have been used. Emphasis is placed on the strength of combining complementary techniques. Finally, we outline our views on the potential of TRIS methods in mechanochemical research, towards establishing a new, environmentally benign paradigm in the chemical sciences.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400867 | PMC |
| http://dx.doi.org/10.1002/anie.202117270 | DOI Listing |
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