Microencapsulation technologies have experienced much growth over the past decades and are commonly used for food, cosmetic, pharmaceutical and biomedical applications. Certain application fields impose stricter requirements on the polymer capsules. In many biomedical applications including bioencapsulation, cell therapy and drug delivery applications, capsules are required to have a controlled shape and size, as well as a defined mechanical stability and porosity. This data article reports the alginate capsule production using common centrifugal technology, which enables the production of microcapsules with highly viscous biopolymers. We describe the experimental data generated in a parametric study, where the main control parameters of the centrifugal encapsulation system (alginate viscosity, rotating speed, nozzle diameter, collecting distance) were varied. The geometric properties of the produced hydrogel capsules were analysed by microscope photography and image processing. The dataset presented here contains the experimental data, the raw capsule images, the analysis scripts, the analysed images, and tables with extracted geometric information. All extracted data was compiled into a table containing geometric properties of more than 50000 analysed capsules. These data allow (i) to reproduce quickly the encapsulation experiments and be able to choose in a straight-forward manner the combination of parameters needed in order to generate capsules with desired properties; (ii) to create more general phase diagrams of the centrifugal encapsulation technology which can be widely used for prediction and/or parameter selection; (iii) to analyse more thoroughly the sensitivity of capsule properties to given stages of the encapsulation process. The research article on these data [1] was published in the journal Colloids and Surfaces A: Physicochemical and Engineering Aspect, with the title: Three-dimensional phase diagram for the centrifugal Calcium-alginate microcapsules production technology.
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http://dx.doi.org/10.1016/j.dib.2022.107851 | DOI Listing |
J Bone Joint Surg Am
January 2025
Harris Orthopaedics Laboratory, Massachusetts General Hospital, Boston, Massachusetts.
Background: Periprosthetic joint infections (PJIs) are a major complication of total joint replacement surgeries. This study investigated the enhancement of mechanical properties and antibiotic release in ultra-high molecular weight polyethylene (UHMWPE) through the encapsulation of submicron gentamicin sulfate (GS) particles, addressing the critical need for improved implant materials in orthopaedic surgery, particularly in managing PJIs.
Methods: The present study involved embedding submicron GS particles into UHMWPE flakes at concentrations of 2% to 10% by weight.
AAPS PharmSciTech
January 2025
Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan.
The aim of the present study was to investigate the potential of human plasma derived exosomes for the delivery of hydroxyurea to enhance its therapeutic efficacy in breast cancer. Plasma derived exosomes were isolated using differential centrifugation along with ultrafiltration method. Hydroxyurea was encapsulated in exosomes using a freeze-thaw method.
View Article and Find Full Text PDFFront Pharmacol
January 2025
Institute of Geriatric Medicine, Jiangsu Province Geriatric Hospital, Nanjing, China.
Introduction: , a traditional medicinal plant, is renowned for its therapeutic properties, including the promotion of anti-inflammatory and bile secretion. Notably, it has demonstrated efficacy in the treatment of jaundice. This study aimed to evaluate the potential of -derived exosomes (ACDEs) as a novel therapeutic approach in non-alcoholic fatty liver disease (NAFLD).
View Article and Find Full Text PDFJ Pharm Anal
December 2024
National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Plant-derived nanovesicles have gained attention given their similarity to mammalian exosomes and advantages such as low cost, sustainability, and tissue targeting. Thus, they hold promise for disease treatment and drug delivery. In this study, we proposed a time-efficient method, PEG 8000 combined with sucrose density gradient centrifugation to prepare ginger-derived nanovesicles (GDNVs).
View Article and Find Full Text PDFJ Biotechnol
January 2025
Analysis and Testing Center, Nanjing Normal University, Nanjing 210023, China. Electronic address:
Chondroitin sulfate (CS) is a structurally complex anionic polysaccharide widely used in medical, cosmetic and food applications. Enzymatic catalysis is an important strategy for synthesizing CS with uniform chain lengths and well-defined structures. However, the industrial application of glycosyltransferases is hindered by limitations such as low expression yields, poor stability, and challenges in reuse.
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