Expression of lncRNAs and in Serum From Patients With Behçet's Disease Can Be Used as Predictors of Disease.

Behçet's disease (BD) is a chronic autoimmune disease. The early diagnosis of BD is very important to avoid serious and/or fatal complications such as eye damage, severe neurological involvement, and large vessel occlusion. New, sensitive biomarkers would aid in rapid diagnosis, the monitoring of disease activity, and the response to treatment. This study's aim is to identify two immune system-related BD biomarkers. We measured long non-coding RNAs (lncRNAs) (nuclear-enriched abundant transcript 1), and (lncRNA in dendritic cells) in serum by real-time polymerase chain reaction (RT-PCR) in 52 BD patients and 52 controls. We analyzed the association between and and the clinical parameters of BD. Receiver operating characteristic (ROC) curve analysis was performed to explore the diagnostic performance of the studied genes. Compared to controls, the significant upregulation of {median [interquartile range (IQR)] = 1.68 (0.38-7.7), 0.0001} and downregulation of [median (IQR) = 0.2 (0.12-1.39), 0.03] were detected in the sera collected from BD patients. Higher serum expression levels of and were significantly associated with the following clinical presentations: cutaneous lesions, vascular manifestations, articular manifestations, neurological manifestations, and higher disease activity score. Also, high levels were significantly associated with a negative pathergy test, while higher was significantly associated with a positive family history. ROC curves showed that and levels in serum could be used as predictors of BD with high specificity and fair sensitivity. had an area under the curve (AUC) of 0.692 (95% CI: 0.591-0.794, = 0.001), and had an AUC of 0.615 (95% CI: 0.508-0.723, = 0.043). Serum lncRNAs and are biomarkers for BD.