AI Article Synopsis

  • - Vitamin D plays a role in lung development, but its impact on respiratory distress syndrome (RDS) in extremely preterm (EPT) infants was not well-studied until this research, which investigated the effects of low vitamin D status at birth.
  • - Researchers found that 74% of the studied infants had low vitamin D levels, which correlated with increased need for mechanical ventilation and a higher likelihood of poor respiratory outcomes, especially in those born before 26 weeks of gestation.
  • - The study concluded that low vitamin D levels at birth are linked to adverse respiratory outcomes in infants born before 29 weeks of gestation, indicating a need for larger studies to further explore this association.

Article Abstract

Background: Vitamin D (VitD) is involved in lung development but its influence on respiratory distress syndrome of extremely preterm (EPT) infants have been little investigated. In this study, we examined the influence of low vitamin D status at birth on early respiratory outcomes of this vulnerable infant population.

Methods: Cord blood 25(OH)D levels ≤ 75 nmol/L were considered as Low vitamin D levels. Stepwise logistic regression and classification regression-tree analyses were used and the primary outcome was the combined outcome of death or mechanical ventilation need by the end of the first week (death or MV DoL7) as a marker od RDS severity.

Results: The mean (SD) GA and birth weight were 26 (1.4) weeks and 801 (212) gr, respectively; 81/109 (74%) infants had low 25(OH)D levels. Infants with low VitD levels had 25% higher initial FiO levels ( < 0.05) and were more likely to be mechanically ventilated on DoL7 (36 vs. 7%, < 0.05). Adjusted for gestational age, they had 10-fold higher odds of death or MV DoL7 ( < 0.01). By regression tree analysis, the rate of death or MV DoL7 increased from 18 to 71% in infants with GA < 26 weeks and with cord blood 25(OH)D levels higher and lower than 74 nmol/L, respectively ( < 0.05).

Conclusion: Low vitamin D levels at birth are associated with early adverse respiratory outcomes in infants with GA less 29 weeks. Further largest studies are needed to confirm this association.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814585PMC
http://dx.doi.org/10.3389/fped.2021.790839DOI Listing

Publication Analysis

Top Keywords

low vitamin
16
vitamin levels
12
25ohd levels
12
death dol7
12
levels
8
levels birth
8
birth early
8
early respiratory
8
gestational age
8
respiratory outcomes
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!