AI Article Synopsis
- - The study examined the lipid profiles and gut bacteria of 27 pregnant women with hypothyroidism compared to 28 normal pregnant women, using advanced laboratory techniques for analysis.
- - Results showed that women with hypothyroidism had higher inflammation markers and lower birth weights, along with significant differences in lipid metabolites and gut microflora diversity.
- - It concluded that these differences in lipid metabolism and gut bacteria could be linked to negative pregnancy outcomes, suggesting further research on their interactions might help understand hypothyroidism in pregnancy better.
Article Abstract
Objective: To investigate the lipid profiles and intestinal microflora in pregnant patients with hypothyroidism and their correlation with pregnancy outcomes.
Methods: In total, 27 pregnant women with hypothyroidism (study case) and 28 normal pregnant women (control group) were enrolled in this study. The lipid profiles and intestinal microflora in the two groups were compared using untargeted liquid chromatography-mass spectrometry (LC-MS) and 16S rRNA amplicon sequencing, respectively. The association among the differential metabolites, intestinal microflora, serological indicators and pregnancy outcomes was further analyzed.
Results: Patients in study case had higher C-reactive protein (CRP) levels (P = 0.025) and lower birth weight (P=0.005) than the control group. A total of 42 differential lipid metabolites and 7 enrichment KEGG pathways were obtained between the two groups (VIP ≥ 1, P < 0.05). Ten lipid metabolites can be used as characteristic metabolites of study case, including phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM). The richness and diversity of intestinal microflora in study case were lower than those in the control group (P>0.05). LEfSe analysis revealed that patients in study case had higher abundance of and and lower abundance of than the control group (P < 0.05). was positively correlated with SM and negatively correlated with PC and PE; the CRP level and were positively correlated; the neonatal weight and PC level were negatively correlated (P < 0.05).
Conclusion: The lipid profile and intestinal microflora of pregnant women with hypothyroidism significantly differed from those of normal pregnant women and were associated with adverse pregnancy outcomes. The interaction between lipid metabolism and intestinal microflora may be a potential target for further studies investigating the pathogenesis of hypothyroidism during pregnancy.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807684 | PMC |
| http://dx.doi.org/10.3389/fendo.2021.792536 | DOI Listing |
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