Within China's hierarchical medical system, many patients seek medical care in different hospitals independently without integrated management. As a result, multi-hospital visiting is associated with fragmented service utilization and increased incidence of polypharmacy behaviors, especially for patients with chronic disease. It has been confirmed that factors from the perspective of patients may cause polypharmacy behaviors in Chinese community patients; whether having a usual primary care provider for chronic disease patients could reduce the polypharmacy behaviors and the effect size remains unanswered, and that is what our study aimed to answer. Our study adopted a cluster sampling method to select 1,196 patients with hypertension or diabetes and measured some information about them. The propensity score weighting method was adopted to eliminate the influence of confounding bias, and then a multivariate logistic regression model was conducted to test the relationship between having a usual primary care provider and polypharmacy behaviors. Patients without usual primary care providers were significantly correlated with polypharmacy behaviors (OR = 2.40, 95%CI: 1.74-3.32, < 0.001), and the corresponding marginal effect is 0.09 (95%CI: 0.06-0.12). Patients who suffer from two kinds of diseases (OR = 3.05, 95%CI: 1.87-5.10, < 0.001), with more than three kinds of diseases (OR = 21.03, 95%CI: 12.83-35.65, < 0.001), with disease history of 20 years and above (OR = 1.66, 95%CI: 1.14-2.42, = 0.008), who communicate frequently with doctors (OR = 3.14, 95%CI: 1.62-6.19, < 0.001), alcoholic patients (OR = 2.14, 95%CI: 1.08-4.19, = 0.027), who used to have meat-based food (OR = 1.42, 95%CI: 1.00-2.00, = 0.049), and have vegetarian-based diet (OR = 1.42, 95%CI: 1.00-2.00, = 0.049) are more likely to have polypharmacy behaviors, while patients aged between 65 and 75 years (OR = 0.50, 95%CI: 0.33-0.77, = 0.020), used to be brain workers (OR = 0.67, 95%CI: 0.45-0.99, = 0.048), with disease history between 10 and 20 years (OR = 0.56, 95%CI: 0.37-0.83, = 0.005), have had adverse drug reactions (OR = 0.64, 95%CI: 0.45-0.93, = 0.019), and participated in medical insurance for urban and rural residents (OR = 0.35, 95%CI: 0.21-0.58, < 0.001) were less likely to have polypharmacy behaviors. The results suggest that having a usual primary care provider may reduce the incidence of having polypharmacy behaviors; we can take intervention measures to promote establishing a long-term relationship between patients and primary care providers.
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http://dx.doi.org/10.3389/fphar.2021.802097 | DOI Listing |
Front Med (Lausanne)
January 2025
Ethiopian Statistical Services, Bahirdar, Ethiopia.
Background: Irrational use of medicines is a problem globally that soon needs to be addressed. According to estimates from the World Health Organization, almost half of all medications were improperly prescribed. This study aimed to assess the drug prescribing patterns based on World Health Organization drug use indicators in the dermatology outpatient department of Injibara General Hospital.
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January 2025
Institute for Clinical Epidemiology and Biometry, Julius-Maximilian University Würzburg, Würzburg, Germany.
Background: The treatment of metastatic breast cancer (mBC) focuses on prolonging patient survival, providing adequate symptom management, and maintaining quality of life (QoL). This includes supportive therapy to prevent or treat potential side effects and handle comorbidities. The combination of mBC therapy, supportive therapy, and treatment for comorbidities increases the risk for polypharmacy, potential drug-drug interactions (pDDI), potentially inappropriate medication (PIM), and potentially missing drugs (pMD).
View Article and Find Full Text PDFPharmacoepidemiol Drug Saf
February 2025
Division of Clinical Pharmacy, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.
Purpose: To characterize trajectories of nephrotoxic potential (NxP) drug use among older adults with Type 2 Diabetes (T2D) treated with SGLT2is and identify associated patient characteristics.
Methods: Using 2012-2019 Medicare data, we selected patients with T2D who filled at least one prescription for SGLT2is. Index date was the date of the first SGLT2i prescription filled.
BMC Med
January 2025
Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, UK.
Background: Polypharmacy (i.e., treatment with ≥ 5 drugs) is common in patients with atrial fibrillation (AF) and has been associated with suboptimal management and worse outcomes.
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January 2025
The Dementia Centre, HammondCare, St Leonards, NSW, Australia.
Background And Objectives: Despite their limited benefits and serious adverse effects, psychotropics remain frequently prescribed for neuropsychiatric symptoms (NPS) of dementia. Psychotropic polypharmacy, the use of two or more concomitant psychotropic medications, is therefore not recommended for people with dementia. The objectives of this study were to investigate the prevalence of psychotropic polypharmacy in Australians living with dementia whose caregivers sought external NPS support from Dementia Support Australia (DSA; the national provider of NPS support) and the association of psychotropic polypharmacy with their demographics and NPS characteristics.
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