There has been an emergence of permanent macular injury due to the misuse of handheld laser pointers. The clinical phenotype of laser-induced maculopathy can mimic hereditary retinal dystrophies. This report describes the clinical phenotype and the results of multimodal imaging in a 27-year-old woman who was referred with a bilateral progressive decrease in vision over 2 months. She was initially diagnosed elsewhere with hereditary macular dystrophy. Examination of her fundus showed bilateral creamy-to-gray irregular lesions in the posterior pole. The results of multimodal imaging of her retina suggested self-inflicted laser-induced maculopathy. The patient was referred to a psychiatrist with a working diagnosis of factitious disorder. A high index of suspicion and the utilization of multimodal imaging allowed early and correct diagnosis and prevented further loss of vision.
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http://dx.doi.org/10.4103/meajo.meajo_234_21 | DOI Listing |
Int Immunopharmacol
January 2025
Department of Geriatrics, Qilu Hospital of Shandong University, Jinan, Shandong Province, China; Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan, Shandong Province, China; Jinan Clinical Research Center for Geriatric Medicine (202132001), Jinan, Shandong Province, China. Electronic address:
Inflammation is hypothesized to have essential functions in the development of wet age-related macular degeneration (AMD). Polymorphonuclear neutrophils (PMNs), recognized as major players in inflammation, are typically the first leukocytes to be recruited to an inflammatory site. Previous studies have identified neutrophil aggregates in the lesion site of the choroidal neovascularization model, and systemic depletion of neutrophils in adult mice is associated with reduced choroidal neovascularization (CNV) area, suggesting a pivotal role of PMNs in CNV pathogenesis.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
December 2024
4D Molecular Therapeutics, Emeryville, California, United States.
Purpose: Intravitreal delivery of therapeutic transgenes to the retina via engineered viral vectors can provide sustained local concentrations of therapeutic proteins and thus potentially reduce the treatment burden and improve long-term vision outcomes for patients with neovascular (wet) age-related macular degeneration (AMD), diabetic macular edema (DME), and diabetic retinopathy.
Methods: We performed directed evolution in nonhuman primates (NHP) to invent an adeno-associated viral (AAV) variant (R100) with the capacity to cross vitreoretinal barriers and transduce all regions and layers of the retina following intravitreal injection. We then engineered 4D-150, an R100-based genetic medicine carrying 2 therapeutic transgenes: a codon-optimized sequence encoding aflibercept, a recombinant protein that inhibits VEGF-A, VEGF-B, and PlGF, and a microRNA sequence that inhibits expression of VEGF-C.
Messenger RNA (mRNA)-based therapies are a promising approach to medical treatment. Except for infectious diseases, no other disease has mRNA-based therapies available. The eye is an ideal model for mRNA therapeutic development because it requires limited dosing.
View Article and Find Full Text PDFBiomedicines
November 2024
Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou 310051, China.
/galectin-3 plays a pivotal role in many vascular diseases. However, the involvement of /galectin-3 in eyes with neovascular age-related macular degeneration (nAMD) remains unknown. In the laser-induced CNV model, a whole mount retina stained with Isolectin B4 and collagen type I revealed the vascular bed and CNV-associated subretinal fibrosis on day 7 after laser treatment.
View Article and Find Full Text PDFSci Rep
November 2024
Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China.
Abnormal growth of blood vessels (choroidal neovascularization) can lead to age-related macular degeneration (AMD) and eventually cause vision loss due to detachment of the retinal pigmented epithelium. This indicates that choroidal neovascularization is important for the treatment of AMD. The circadian clock in the mammalian retina is responsible for controlling various functions of the retina, enabling it to adjust to changes in light and darkness.
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