Tuberculosis (TB) is chronic granulomatous infection caused by bacteria, , which primarily involves the lungs. Abdominal TB is an extrapulmonary disease which can mimic malignancy, especially in women with ascites, weight loss, and high cancer antigen-125 levels. Here, we report a case of young female, where clinical and radiological features were suggestive of ovarian malignancy. However, the pattern of uptake on flourine-18 fluorodeoxyglucose positron emission tomography/computed tomography raised the suspicion of a chronic infectious disease. The final diagnosis was confirmed as TB by cytology and started on antituberculous treatment. She had a good response and remission of lesions after 4 months of treatment.
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http://dx.doi.org/10.4103/ijnm.ijnm_28_21 | DOI Listing |
BJS Open
December 2024
Department of Obstetrics and Gynecology, and Catharina Cancer Institute, Catharina Hospital, Eindhoven, The Netherlands.
Background: Ovarian cancer is the leading cause of death among gynaecological cancers. The identification of the fallopian tube epithelium as the origin of most ovarian cancers introduces a novel prevention strategy by removing the fallopian tubes during an already indicated abdominal surgery for another reason, also known as an opportunistic salpingectomy. This preventive opportunity is evidence based, recommended and established at the time of gynaecologic surgery in many countries worldwide.
View Article and Find Full Text PDFJ Biochem Mol Toxicol
February 2025
Department of Gynecology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China.
Lycopene (LYC) is an extremely powerful antioxidant with the potential to treat a range of diseases and to inhibit ferroptosis. This research aims to elucidate how LYC impacts polycystic ovarian syndrome (PCOS) and the action mechanisms. A PCOS rat model was constructed by injecting DHEA.
View Article and Find Full Text PDFCancer Cell Int
January 2025
Department of Gynecology, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China.
Background: Ovarian cancer (OC) remains a lethal gynecological malignancy with an alarming mortality rate, primarily attributed to delayed diagnosis and a lack of effective treatment modalities. Accumulated evidence highlights the pivotal role of reprogrammed lipid metabolism in fueling OC progression, however, the intricate underlying molecular mechanisms are not fully elucidated.
Methods: DLAT expression was assessed in OC tissues and cell lines by immunohistochemistry, western blot and qRT-PCR analysis.
Mol Med
January 2025
Reproduction and Genetics Center, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, 42 Wenhua West Road, Lixia District, Jinan, 250014, Shandong, China.
Background: Polycystic ovary syndrome (PCOS) is a common gynecological disease accompanied by multiple clinical features, including anovulation, hyperandrogenism, and polycystic ovarian morphology, leading to infertility. Formononetin (FMN), which is a major bioactive isoflavone compound in Astragalus membranaceus, exerts anti-inflammatory effects. However, whether FMN is effective in the treatment of PCOS remains unknown.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, Sichuan, People's Republic of China.
Lysine acetyltransferase 2B (KAT2B) plays a crucial role in epigenetic regulation and tumor pathogenesis. Our study investigates KAT2B's function in epithelial ovarian cancer (EOC) using in vivo and in vitro methods. Immunohistochemistry showed the KAT2B expression in EOC tissues.
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