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A systemically administered detoxified TLR4 agonist displays potent antitumor activity and an acceptable tolerance profile in preclinical models.
Front Immunol
June 2023
INSERM U1052, CNRS UMR 5286, Centre de Recherche en Cancérologie de Lyon, Université de Lyon, Lyon, France.
Bacterial lipopolysaccharides (LPS) are potent innate immunostimulants targeting the Toll-like receptor 4 (TLR4), an attractive and validated target for immunostimulation in cancer therapy. Although LPS possess anti-tumor activity, toxicity issues prevent their systemic administration at effective doses in humans. We first demonstrated that LPS formulated in liposomes preserved a potent antitumor activity upon systemic administration in syngeneic models, and significantly enhance the antitumor activity of the anti-CD20 antibody rituximab in mice xenografted with the human RL lymphoma model.
View Article and Find Full Text PDFEarly Everolimus-Facilitated Reduced Tacrolimus in Liver Transplantation: Results From the Randomized HEPHAISTOS Trial.
Liver Transpl
June 2022
Department of Hepatobiliary Surgery and Visceral Transplantation University Medical Center Hamburg-Eppendorf Hamburg Germany Department of General, Visceral and Transplant Surgery University Hospital Heidelberg Heidelberg Germany Department of General, Visceral, Thoracic, Transplant and Pediatric Surgery University Medical Center Schleswig-Holstein Kiel Germany Department of Surgery University Hospital Regensburg Regensburg Germany Department of General, Visceral and Transplant Surgery Charité-Universitätsmedizin Berlin Berlin Germany Department of General, Visceral and Transplantation Surgery University Hospital Essen Essen Germany Department of General, Visceral and Transplant Surgery University Hospital Aachen Aachen Germany Novartis Pharma GmbH Nürnberg Germany Organ Transplantation Center The First Affiliated Hospital of University of Science and Technology of ChinaAnhui Provincial Hospital Hefei China General, Visceral and Transplant SurgeryDepartment of Surgery Medical University of Graz Graz Austria Department of General, Visceral and Transplantation Surgery University Hospital Münster Münster Germany Department of GeneralVisceral and Transplant Surgery University Hospital Aachen Aachen Germany Department of General Surgery Maastricht University Medical Centre (MUMC) Maastricht the Netherlands.
Everolimus-facilitated reduced-exposure tacrolimus (EVR + rTAC) at 30 days after liver transplantation (LT) has shown advantages in renal preservation. This study evaluated the effects of early initiation of EVR + rTAC in de novo LT recipients (LTRs). In HEPHAISTOS (NCT01551212, EudraCT 2011-003118-17), a 12-month, multicenter, controlled study, LTRs were randomly assigned at 7 to 21 days after LT to receive EVR + rTAC or standard-exposure tacrolimus (sTAC) with steroids.
View Article and Find Full Text PDFAtrophy of calf muscles by unloading results in an increase of tissue sodium concentration and fat fraction decrease: a Na MRI physiology study.
Eur J Appl Physiol
August 2017
Division of Space Physiology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.
Purpose: Na MRI demonstrated increased tissue sodium concentrations in a number of pathologies. Acute atrophy results in muscle fibre volume shrinking that may result in a relative increase of extracellular volume and might affect sodium concentration. Thus, we hypothesized that local unloading of the calf muscles would lead to a decrease in muscle volume and an increase in muscle tissue sodium concentration.
View Article and Find Full Text PDFUsing the Hephaistos orthotic device to study countermeasure effectiveness of neuromuscular electrical stimulation and dietary lupin protein supplementation, a randomised controlled trial.
PLoS One
August 2017
Division of Space Physiology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.
Purpose: The present study investigated whether neuromuscular electrical stimulation for 20 min twice a day with an electrode placed over the soleus muscle and nutritional supplementation with 19 g of protein rich lupin seeds can reduce the loss in volume and strength of the human calf musculature during long term unloading by wearing an orthotic unloading device.
Methods: Thirteen healthy male subjects (age of 26.4 ± 3.
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