In vitro studies have shown that cobalt substances predominantly induce pre-inflammatory biomarkers, resulting in a grouping of substances either predicted to cause inflammation following inhalation, or those with a different reactivity profile (poorly-reactive). There is a lack of data on whole-organ lung responses following inhalation of these substances, especially relating to the poorly-reactive group. It is of interest to generate tissue-specific histopathological correlation to better ascertain the predictive nature of the lower tier tests (i.e. tier 1 - bioelution, tiers 2a and b - in vitro markers and ToxTracker testing), in order to understand the type of effects caused by the poorly-reactive group and to gauge long-term effects. Eight cobalt substances were tested in vivo in a customized 4-h toxicity test; with animals sacrificed up to 14-days post-exposure. Histopathological severity scores were assigned based on inflammatory and pre-carcinogenic markers. A clear pattern emerged, with the reactive substances causing a persistent increase in one or more of the selected markers, and absence of these markers with poorly-reactive substances. Longer-term studies should be conducted to investigate the repeated dose effects of the poorly-reactive substances.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.yrtph.2022.105127 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Investigating residual trace metals in recombinant monoclonal antibodies to facilitate drug development with LC-UV-ICPMS-HRMS.
Anal Chim Acta
February 2025
Regeneron Pharmaceuticals, Inc., Tarrytown, NY, 10591-6707, USA.
Background: The biopharmaceutical industry is increasingly interested in the analysis of trace metals due to their significant impact on product quality and drug safety. Certain metals can potentially accelerate the formation of degradants or aggregates in biotherapeutic proteins, leading to drug product quality concerns. A better understanding of metal-mAb interactions would aid in the development of purification processes and formulations, thereby ensuring better drug quality and safety.
View Article and Find Full Text PDFSelf-signaling colorimetric sensor for selective detection of dopamine based on CoFeO nanozyme accelerated dopamine polymerization.
Anal Chim Acta
February 2025
Key Laboratory of Water Security and Water Environment Protection in Plateau Intersection (NWNU), Ministry of Education, Key Lab of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, 730070, Lanzhou, Gansu, China. Electronic address:
Background: Reliable and selective detection of dopamine is crucial for the early diagnosis of various diseases. Transition metal based-nanozymes have shown great promise in the field of colorimetric detection of dopamine due to their remarkable stability and exceptional catalytic efficiency. However, these transition metal-based nanozymes typically function through a chromogenic reaction that relies on additional organic substrates, such as 3,3',5,5'-tetramethylbenzidine, to generate a detectable signal.
View Article and Find Full Text PDF"Skin Whitening Creams: Cosmetovigilance.".
Curr Pharm Biotechnol
January 2025
School of Physiotherapy and Rehabilitation, Jamia Hamdard University, India.
Cosmeceutical products such as skin-lightening agents have been used globally to enhance skin tone and obtain a magnificent outward appearance. The pigment known as melanin, produced by melanocytes, imparts skin color. The Cosmetic Europe survey testifies that most people believe that cosmetics enhance one's quality of life.
View Article and Find Full Text PDFSwitch-Type Electrochemiluminescence Aptasensor for AFB1 Detection Based on CoS Quantum Dots Encapsulated in Co-LDH and a Ferrocene Quencher.
Anal Chem
January 2025
Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.
Among the various aflatoxin B1 (AFB1) assays, performing accurate detection is difficult because false positives and false negatives are frequent due to limited sensitivity, expensive equipment, or inadequate pretreatment during operation. Here, an "off-on" switch-type electrochemiluminescence (ECL) aptasensor armed with cobalt-sulfur quantum dots was encapsulated in hollow cobalt-layered double hydroxide nanocages as an enhanced luminescent probe (Co-LDH@QDs), and a ferrocene-modified aptamer (Fc-APT) was used as a luminescent quencher. In general, when Fc-APT was hybridized with complementary DNA modified with a DNA nanotetrahedron, electron transfer between ferrocene and Co-LDH@QDs was facilitated, leading to efficient quenching of the ECL intensity into an "off" state in the absence of AFB1.
View Article and Find Full Text PDFCopper-Cobalt Nanozyme Mimicking Laccase for Sensitive Colorimetric Determination of Cannabidiol in Food and Cosmetics.
Luminescence
December 2024
Key Laboratory of Intelligent Drug Control, Ministry of Education, Yunnan Key Laboratory of Intelligent Drug Control, Faculty of Narcotics Control, Yunnan Police College, Kunming, China.
In colorimetric analysis, nanozymes are invaluable tools due to their simple production, long-lasting stability, and adaptable enzymatic activity, which enable them to induce changes in substrate color. In this study, a simple nanozyme-based colorimetric sensor was developed to detect cannabidiol (CBD) by using the laccase activity of the self-made MOF with copper and cobalt loading (Cu/Co@MOF) nanozyme, which was synthesized using a one-pot microwave method. The Cu/Co@MOF has the ability to catalyze the coupling reaction between 4-AP and various phenolic substrates, thereby converting colorless phenolic substrates into red substances.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!