Intestinal pathogens must combat host and microbiota-associated resistance to establish an infection. A new study (Shelton et al.) highlights how Salmonella manipulates the mammalian host to produce anaerobic respiratory electron acceptors, allowing catabolism of propionate and providing a competitive edge to Salmonella residing in the gut.
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http://dx.doi.org/10.1016/j.tim.2022.01.011 | DOI Listing |
Cell Commun Signal
October 2024
Division of Life Sciences, Institute of Advanced Study in Science and Technology (IASST), Guwahati, 781035, Assam, India.
ISME J
January 2024
Department of Cell and Molecular Biology, Colorado State University, Plant Sciences Bldg. 307 University Ave, Fort Collins, CO 80523, United States.
Salmonella enterica serovar Typhimurium is a pervasive enteric pathogen and ongoing global threat to public health. Ecological studies in the Salmonella impacted gut remain underrepresented in the literature, discounting microbiome mediated interactions that may inform Salmonella physiology during colonization and infection. To understand the microbial ecology of Salmonella remodeling of the gut microbiome, we performed multi-omics on fecal microbial communities from untreated and Salmonella-infected mice.
View Article and Find Full Text PDFCell Host Microbe
October 2024
Institute of Microbiology, Department of Biology, ETH Zürich, Zürich, Switzerland. Electronic address:
How enteric pathogens adapt their metabolism to a dynamic gut environment is not yet fully understood. To investigate how Salmonella enterica Typhimurium (S.Tm) colonizes the gut, we conducted an in vivo transposon mutagenesis screen in a gnotobiotic mouse model.
View Article and Find Full Text PDFmSphere
October 2024
Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Cell Host Microbe
October 2024
Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA. Electronic address:
The gut microbiota prevents harmful microbes from entering the body, a function known as colonization resistance. The enteric pathogen Salmonella enterica serovar (S.) Typhimurium uses its virulence factors to break colonization resistance through unknown mechanisms.
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