AI Article Synopsis
- This study aimed to explore the genetic and prognostic traits of patients with acute myeloid leukemia with myelodysplasia-related changes (AML-MRC), analyzing data from 230 non-M3 AML patients at Ningbo First Hospital.
- Out of the patients, 58 were newly diagnosed with AML-MRC, and genetic testing revealed that 59.2% had chromosomal abnormalities, with specific mutations like ASXL1 and TET2 being most common.
- The research found that patients with high complex karyotypes, 5q- abnormalities, and TP53 mutations had significantly poorer overall survival rates, highlighting the distinct genetic profile of AML-MRC and its impact on patient prognosis.
Article Abstract
Objective: To investigate the genetic and prognostic characteristics of acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) patients.
Methods: There were 230 non-M3 AML patients treated in Ningbo First Hospital enrolled, among which 58 patients were newly diagnosed AML-MRC, the patients were followed up and SPSS 25.0 was used to statistically analyze.
Results: There were 49 patients performed genetic testing, 29 patients (59.2%) showed chromosomal abnormalities, including 7q- 8 cases (16.3%), 5q- 6 cases (12.2%), 5 cases (10.2%) of 17p abnormalities, 13 cases (26.5%) of highly abnormal complex karyotypes (CK) (≥5 unrelated chromosomal abnormalities), CK contained chromosomal abnormalities such as +8, 5q-, and 12 cases (24.5%) of monosomal karyotypes (MK). Genetic testing was performed in 37 patients, and 24 (64.9%) patients showed genetic mutations, among which ASXL1 mutation was the most common (8 cases, 21.6%), followed by TET2 mutation in 6 cases (16.2%). Kaplan-Meier analysis showed that AML-MRC patients with high CK (P=0.012), 5q- abnormalities (P=0.038), and TP53 mutations (P=0.008) had poor overall survival.
Conclusion: AML-MRC has unique genetic characteristics, and high CK, 5q- and TP53 mutations are poor prognostic factors.
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| http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2022.01.004 | DOI Listing |
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