AI Article Synopsis
- The study investigates the role of thymic stromal lymphopoietin (TSLP) in childhood asthma by comparing TSLP levels in asthmatic children to healthy controls and examining its association with various asthma phenotypes and disease activity.
- Results show that children with asthma have higher serum TSLP concentrations compared to healthy peers, but TSLP levels do not significantly differ among various asthma types (like allergic or non-allergic) and do not correlate with lung function indicators.
- The conclusion suggests that while TSLP is elevated in asthmatic children, it is not a useful biomarker for asthma exacerbations or distinguishing between different asthma phenotypes.
Article Abstract
Background: Thymic stromal lymphopoietin (TSLP), an epithelium-derived pro-inflammatory cytokine, activates distinct immune and non-immune cells. It has been shown to be a master regulator of type 2 immune responses. Limited information is available on TSLP in childhood asthma. The aim of the present study was to find out whether there is association between TSLP concentrations and asthma phenotypes or disease activity.
Methods: A total of 207 children with asthma and 100 healthy children aged 1-13 years were enrolled. This study examined serum TSLP concentrations using ELISA Kit in asthma patients and controls, analyzed its correlation with asthma phenotypes and pulmonary function. We also examined TSLP concentrations in 23 patients during stable asthma and in acute asthma exacerbation.
Results: The serum concentrations of TSLP were significantly elevated in asthma patients compared with healthy controls (p < 0.05), but there was no significant difference (p > 0.05) in TSLP concentrations between three different asthma phenotypes (allergic asthma, virus induced asthma and nonallergic asthma). There was no significant correlation between TSLP concentrations and FEV1pred% (r = 0.01, p > 0.05). In the acute asthma exacerbation TSLP concentrations were not significantly different than in stable phase of disease (p > 0.05).
Conclusion: Children with asthma have higher serum TSLP concentrations when compared to healthy controls. TSLP does not seem to be a biomarker of disease exacerbation in children. Different asthma phenotypes have similar TSLP concentration profile in peripheral blood and TSLP does not seem to be useful biomarker in asthma phenotyping in children.
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| http://dx.doi.org/10.1016/j.rmed.2022.106757 | DOI Listing |
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