Four new polycyclic polyprenylated acylphloroglucinols from Hypericum wilsonii and their glucose uptake bioactivities.

Wilsonglucinols H-K (1-4), four new polycyclic polyprenylated acylphloroglucinols (PPAPs), and eight known compounds (5-12) were isolated and identified from the aerial parts of Hypericum wilsonii. Their planner structures were confirmed via extensive NMR and HRESIMS data analysis. The absolute configurations of the new compounds were mainly determined by NMR calculation and electronic circular dichroism (ECD) calculation. Compounds 1, 6, 8, and 10 showed glucose uptake activities at 30 μg/mL, in which compound 6 showed the strongest effect and increased the glucose uptake by 2.73 folds.