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| http://dx.doi.org/10.1007/s10334-022-01002-w | DOI Listing |
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Learning-based motion artifact correction in the Z-spectral domain for chemical exchange saturation transfer MRI.
Magn Reson Med
January 2025
Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.
Purpose: To develop and evaluate a physics-driven, saturation contrast-aware, deep-learning-based framework for motion artifact correction in CEST MRI.
Methods: A neural network was designed to correct motion artifacts directly from a Z-spectrum frequency (Ω) domain rather than an image spatial domain. Motion artifacts were simulated by modeling 3D rigid-body motion and readout-related motion during k-space sampling.
Alterations in Volume and Intrinsic Resting-State Functional Connectivity Detected at Brain MRI in Individuals with Opioid Use Disorder.
Radiology
December 2024
From the Department of Radiology & Biomedical Imaging (S.M., J.A., F.T., C.L., R.T.C., D.S.), Department of Internal Medicine (A.I., H.Y.), Department of Urology (S.L.), Department of Pulmonary, Critical Care & Sleep Medicine (I.K.), Department of Psychiatry (S.W.Y., D.T.B.), Child Study Center (S.W.Y., D.T.B., D.S.), Yale Center for Clinical Investigation (C.A.H.), Department of Neurosurgery (R.T.C.), and Department of Statistics & Data Science (D.S.), Yale School of Medicine, 300 Cedar St, New Haven, CT 06519; Department of Health Policy, Vanderbilt University, Nashville, Tenn (H.P.); Interdepartmental Neuroscience Program, Yale University, New Haven, Conn (J.Y., S.W.Y., R.T.C., D.S.); Department of Internal Medicine, Roger Williams Medical Center, Providence, RI (G.S.); Yale School of Nursing, New Haven, Conn (S.L., U.N.E., S.J.); Yale University Program of Aging, Yale University, New Haven Conn (S.T.); Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Conn (A.R.); Department of Psychiatry, Brigham and Women's Hospital, Boston, Mass (A.S.G.); Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, Conn (R.T.C., D.S.); Department of Research, APT Foundation, New Haven, Conn (D.T.B.); School of Nursing, University of Connecticut, Mansfield, Conn (N.S.R.); and Clinical Epidemiology Research Center, VA CT Health Care Center, West Haven, Conn (H.Y.).
Article Synopsis
- Research indicates that structural and functional brain changes are linked to opioid use disorder (OUD), but earlier studies often had small participant groups, especially fewer women, and focused on single types of brain analysis.
- This study aimed to use comprehensive brain imaging techniques, including T1-weighted MRI and resting-state fMRI, to better identify these brain alterations in OUD patients undergoing methadone treatment compared to healthy controls.
- Results showed significant differences in brain volumes between the two groups, with OUD participants having smaller thalamus and temporal lobe sizes but larger brainstem and cerebellum volumes, and there were sex-based differences in the medial prefrontal cortex volumes.
Motion and magnetic field inhomogeneity correction techniques for chemical exchange saturation transfer (CEST) MRI: A contemporary review.
NMR Biomed
January 2025
Russell H. Morgan Department of Radiology and Radiological Sciences, Division of MR Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has emerged as a powerful imaging technique sensitive to tissue molecular composition, pH, and metabolic processes in situ. CEST MRI uniquely probes the physical exchange of protons between water and specific molecules within tissues, providing a window into physiological phenomena that remain invisible to standard MRI. However, given the very low concentration (millimolar range) of CEST compounds, the effects measured are generally only on the order of a few percent of the water signal.
View Article and Find Full Text PDFPathological tissue changes in brain tumors affect the pH-sensitivity of the T1-corrected apparent exchange dependent relaxation (AREX) of the amide protons.
NMR Biomed
January 2025
University Hospital, Institute of Neuroradiology, Goethe University Frankfurt, Frankfurt, Germany.
Measuring the intracellular pH (pHi) is of interest for brain tumor diagnostics. Common metrics of CEST imaging like the amide proton transfer-weighted (APTw) MTR are pHi sensitive and allow differentiating malignant tumor from healthy tissue. Yet, the image contrast also depends on additional magnetization transfer effects and T1.
View Article and Find Full Text PDFSensitive optical coherence tomography angiography parameters detecting retinal vascular changes in Behcet's uveitis.
Photodiagnosis Photodyn Ther
October 2024
The First Affiliated Hospital of Chongqing Medical University, Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing, China. Electronic address:
Purpose: To compare the retinal parameters in Behcet's uveitis (BU) patients with wide-field swept-source optical coherence tomography angiography (SS-OCTA) and find a sensitive OCTA parameter.
Methods: Fifty-two eyes from 52 quiescent BU patients and 50 healthy eyes were included. All subjects underwent SS-OCTA examinations with 12 × 12 mm region.
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