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Exploratory analysis of immunomodulatory factors identifies L1CAM as a prognostic marker in alveolar soft-part sarcoma.
Ther Adv Med Oncol
November 2024
Health Research Institute Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Reyes Católicos 2, Madrid 28040, Spain.
Background: Alveolar soft-part sarcoma (ASPS) is a rare tumor driven by the ASPSCR1-TFE3 fusion protein, with a propensity for metastasis. Prognostic factors remain poorly understood, and traditional chemotherapies are largely ineffective. Recent interest lies in immune checkpoint inhibitors (ICIs), yet predictive biomarkers for treatment response are lacking.
View Article and Find Full Text PDFFunctional Relationships between L1CAM, LC3, ATG12, and Aβ.
Int J Mol Sci
October 2024
Department of Cell Biology and Neuroscience, Keck Center for Collaborative Neuroscience, Rutgers University, 604 Allison Road, Piscataway, NJ 08854, USA.
Abnormal protein accumulations in the brain are linked to aging and the pathogenesis of dementia of various types, including Alzheimer's disease. These accumulations can be reduced by cell indigenous mechanisms. Among these is autophagy, whereby proteins are transferred to lysosomes for degradation.
View Article and Find Full Text PDFThe Conundrum of Mechanics Versus Genetics in Congenital Hydrocephalus and Its Implications for Fetal Therapy Approaches: A Scoping Review.
Prenat Diagn
October 2024
UCSF Center for Maternal-Fetal Precision Medicine, University of California San Francisco, San Francisco, California, USA.
Article Synopsis
- Recent advances in gene therapy show promise for treating single-gene disorders, particularly primary hydrocephalus (CH), which is linked to genetic causes and significant childhood health issues.
- Prenatal ultrasound can detect ventriculomegaly early, but existing surgical treatments only provide limited benefits and don't address root genetic problems.
- Prenatal somatic cell gene therapy (PSCGT) could offer hope by targeting specific genetic mutations before birth, potentially improving long-term neurodevelopmental outcomes, although more research is needed to confirm its effectiveness and safety.
Congenital hydrocephalus: a review of recent advances in genetic etiology and molecular mechanisms.
Mil Med Res
August 2024
Medical School, Tianjin University, Tianjin, 300072, China.
The global prevalence rate for congenital hydrocephalus (CH) is approximately one out of every five hundred births with multifaceted predisposing factors at play. Genetic influences stand as a major contributor to CH pathogenesis, and epidemiological evidence suggests their involvement in up to 40% of all cases observed globally. Knowledge about an individual's genetic susceptibility can significantly improve prognostic precision while aiding clinical decision-making processes.
View Article and Find Full Text PDFKLF12 interacts with TRIM27 to affect cisplatin resistance and cancer metastasis in esophageal squamous cell carcinoma by regulating L1CAM expression.
Drug Resist Updat
September 2024
Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:
Krüppel-like factor 12 (KLF12) has been characterized as a transcriptional repressor, and previous studies have unveiled its roles in angiogenesis, neural tube defect, and natural killer (NK) cell proliferation. However, the contribution of KLF12 to cancer treatment remains undefined. Here, we show that KLF12 is downregulated in various cancer types, and KLF12 downregulation promotes cisplatin resistance and cancer metastasis in esophageal squamous cell carcinoma (ESCC).
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