The Choiyoi Magmatic Province represents a major episode of silicic magmatism in southwestern Pangea in the mid-Permian-Triassic, the origin of which remains intensely debated. Here, we integrate plate-kinematic reconstructions and the lower mantle slab record beneath southwestern Pangea that provide clues on late Paleozoic-Mesozoic subducting slab configurations. Also, we compile geochronological information and analyze geochemical data using tectono-magmatic discrimination diagrams. We demonstrate that this magmatic event resulted from a large-scale slab loss. This is supported by a paleogeographic coincidence between a reconstructed 2,800-3,000-km-wide slab gap and the Choiyoi Magmatic Province and geochemical data indicating a slab break-off fingerprint in the latter. The slab break-off event is compatible with Permian paleogeographic modifications in southwestern Pangea. These findings render the Choiyoi Magmatic Province the oldest example of a geophysically constrained slab loss event and open new avenues to assess the geodynamic setting of silicic large igneous provinces back to the late Paleozoic.
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http://dx.doi.org/10.1038/s41467-022-28290-z | DOI Listing |
Nature
December 2024
Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Cancers (Basel)
January 2024
Division of Hematology-Oncology, Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.
Improvements in survival have been made over the past two decades for childhood acute myeloid leukemia (AML), but the approximately 40% of patients who relapse continue to have poor outcomes. A combination of checkpoint-inhibitor nivolumab and azacitidine has demonstrated improvements in median survival in adults with AML. This phase I/II study with nivolumab and azacitidine in children with relapsed/refractory AML (NCT03825367) was conducted through the Therapeutic Advances in Childhood Leukemia & Lymphoma consortium.
View Article and Find Full Text PDFNat Commun
April 2022
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Capital Federal, Argentina.
Nat Commun
February 2022
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Capital Federal, Argentina.
The Choiyoi Magmatic Province represents a major episode of silicic magmatism in southwestern Pangea in the mid-Permian-Triassic, the origin of which remains intensely debated. Here, we integrate plate-kinematic reconstructions and the lower mantle slab record beneath southwestern Pangea that provide clues on late Paleozoic-Mesozoic subducting slab configurations. Also, we compile geochronological information and analyze geochemical data using tectono-magmatic discrimination diagrams.
View Article and Find Full Text PDFCancer Cell
May 2021
Center for Cancer Research, NCI, NIH, 37 Convent Drive, Bethesda, MD 20892, USA. Electronic address:
There is a lack of appropriate melanoma models that can be used to evaluate the efficacy of novel therapeutic modalities. Here, we discuss the current state of the art of melanoma models including genetically engineered mouse, patient-derived xenograft, zebrafish, and ex vivo and in vitro models. We also identify five major challenges that can be addressed using such models, including metastasis and tumor dormancy, drug resistance, the melanoma immune response, and the impact of aging and environmental exposures on melanoma progression and drug resistance.
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