Objective: For older adults receiving long-term care (LTC) at home, little is known about the role of social function in the onset of adverse outcomes, such as death, institutionalization, and functional decline. We examined the association between social function and adverse outcome onset among community-dwelling older adults with mild care needs.
Methods: This two-year longitudinal study recruited non-institutionalized older adults, with mild care need levels, in 2003. Participants were followed regarding the onset of death, institutionalization, and functional decline, after two years. Social function was assessed using four items (friendships, emotional support, instrumental support, and intergenerational interactions) and scored from zero (low) to four (high). Multivariable logistic regression analysis estimated the odds ratios (ORs) and 95% confidence intervals (CIs) for the onset of adverse outcomes, composite of death, institutionalization, and functional decline.
Results: Ultimately, 281 older adults were analyzed. During the observation period, the onset of adverse outcomes was observed in 41.4% of the participants (death, 13.9%; institutionalization, 7.9%; functional decline, 19.5%). Higher social function was inversely associated with adverse outcome onset, even after adjusting for covariates including cognitive function (compared to zero point, ORs [95% CIs] were 0.85 [0.42-1.70] for one, 0.42 [0.19-0.94] for two, and 0.44 [0.20-0.99] for three or more; p = 0.018). Among the sub-items, friendships were associated with lower adverse outcome onset.
Conclusions: Higher social functioning was associated with the low onset of adverse outcomes among older adults under LTC. Enhancing social functions, including friendships, may be crucial for prognosis in LTC.
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http://dx.doi.org/10.1016/j.archger.2022.104631 | DOI Listing |
Endocrinol Diabetes Metab
January 2025
Department of Endocrinology and Metabolism, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Objective: This study investigates the relationship between the albumin-to-creatinine ratio and diabetic retinopathy (DR) in US adults using NHANES data from 2009 to 2016. This study assesses the predictive efficacy of the urinary serum albumin-to-creatinine ratio (UACR/SACR Ratio) against traditional biomarkers such as the serum albumin-to-creatinine ratio (SACR) and urinary albumin-to-creatinine ratio (UACR) for evaluating DR risk. Additionally, the study explores the potential of these biomarkers, both individually and in combination with HbA1c, for early detection and risk stratification of DR.
View Article and Find Full Text PDFDev Med Child Neurol
January 2025
Queensland Cerebral Palsy and Rehabilitation Research Centre, Child Health Research Centre, Faculty of Medicine, The University of Queensland, Brisbane, Australia.
Aim: To identify developmental trajectories of impaired hand function in infants aged 3 to 15 months with unilateral cerebral palsy (CP).
Method: Sixty-three infants (37 male; median gestational age 37 weeks [interquartile range 30-39.1 weeks]) recruited as part of a randomized trial with a confirmed diagnosis of unilateral CP were included.
Dig Dis Sci
January 2025
Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Background: Chronic constipation, diarrhea, and fecal incontinence (FI) are prevalent with significant impact on quality of life and healthcare utilization. Thyroid dysfunction was recognized as a potential contributor to bowel disturbances in selected populations, but the strength/consistency of this association remain unclear.
Aims: To investigate the relationship between thyroid function and bowel health measures (constipation, diarrhea, and FI) in a nationally representative sample of the U.
Metab Brain Dis
January 2025
Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus N, Denmark.
Background & Aims: Hepatic encephalopathy (HE), one of the most serious prognostic factors for mortality in alcohol-related cirrhosis (ALD cirrhosis), is not recorded in Danish healthcare registries. However, treatment of HE with lactulose, the universal first-line treatment, can be identified through data on filled prescriptions. This study aimed to investigate if lactulose can be used as a surrogate marker of HE.
View Article and Find Full Text PDFDrugs Aging
January 2025
Program for the Care and Study of the Aging Heart, Department of Medicine, Weill Cornell Medicine, 420 East 70th St, New York, NY, LH-36510063, USA.
There are several pharmacologic agents that have been touted as guideline-directed medical therapy for heart failure with preserved ejection fraction (HFpEF). However, it is important to recognize that older adults with HFpEF also contend with an increased risk for adverse effects from medications due to age-related changes in pharmacokinetics and pharmacodynamics of medications, as well as the concurrence of geriatric conditions such as polypharmacy and frailty. With this review, we discuss the underlying evidence for the benefits of various treatments in HFpEF and incorporate key considerations for older adults, a subpopulation that may be at higher risk for adverse drug events.
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