AI Article Synopsis
- The COVID-19 pandemic has led to many deaths and a need for new treatments, with factors like age, sex, and vitamin D deficiency linked to worse outcomes.
- Vitamin D is thought to enhance the immune response and may help lessen the severity of COVID-19 in those who are deficient, but the direct connection is unclear.
- The study aims to rigorously test whether high-dose vitamin D supplementation can improve recovery times in vitamin D-deficient COVID-19 patients compared to those receiving standard treatment.
Article Abstract
Background: The coronavirus disease 19 (COVID-19) pandemic has caused millions of deaths, and new treatments are urgently needed. Factors associated with a worse COVID-19 prognosis include old age (> 65 years), ethnicity, male sex, obesity, and people with comorbidities. Furthermore, vitamin D deficiency was reported as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19. According to a recent clinical case series, vitamin D deficiency is a modifiable risk factor, which has the prospect of reducing hospital stay, intensive care, and fatal outcomes. Vitamin D has potent immunomodulatory properties, and its supplementation might improve important outcomes in critically ill and vitamin D-deficient COVID-19 patients. Despite the evidence that supports an association between vitamin D deficiency and COVID-19 severity, there is uncertainty about the direct link. Therefore, the aim of the trial is to assess if high-dose vitamin D supplementation has a therapeutic effect in vitamin D-deficient patients with COVID-19.
Methods: As the trial design, a randomized, placebo-controlled, double-blind, multi-center approach was chosen to compare a high single dose of vitamin D (140,000 IU) followed by treatment as usual (TAU) (VitD + TAU) with treatment as usual only (placebo + TAU) in patients with COVID-19 and vitamin D deficiency.
Discussion: Vitamin D substitution in patients with COVID-19 and vitamin D deficiency should be investigated for efficacy and safety. The study aim is to test the hypothesis that patients with vitamin D deficiency suffering from COVID-19 treated under standardized conditions in hospital will recover faster when additionally treated with high-dose vitamin D supplementation. Latest studies suggest that vitamin D supplementation in patients with COVID-19 is highly recommended to positively influence the course of the disease. With this randomized controlled trial, a contribution to new treatment guidelines shall be made.
Trial Registration: ClinicalTrials.gov NCT04525820 and SNCTP 2020-01401.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814790 | PMC |
| http://dx.doi.org/10.1186/s13063-022-06016-2 | DOI Listing |
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