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http://dx.doi.org/10.1371/journal.pgen.1010048 | DOI Listing |
Cells
October 2023
Cardiovascular Research Section, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Platelet activation during hemostasis and thrombosis is facilitated by agonist-induced inside-out and integrin αβ-initiated outside-in signaling via protein kinases and phosphatases. Pharmacological inhibitor studies suggest that the serine/threonine protein phosphatase 1 (PP1) promotes platelet activation. However, since phosphatase inhibitors block all the isoforms of the catalytic subunit of PP1 (PP1c), the role of specific PP1c isoform in platelet signaling remains unclear.
View Article and Find Full Text PDFDrug Res (Stuttg)
November 2022
Department of Pharmacology, Faculty of Pharmacy, Integral University, Lucknow (India).
Microglia is cells of mesodermal/mesenchymal origin that migrate into the central nervous system (CNS) to form resident macrophages inside the special brain microenvironment. Intact with both neuronal and non-neuronal cells, microglia is highly active cells. Continuous process extension and retraction allows microglia to scan the brain parenchyma for threats.
View Article and Find Full Text PDFComput Intell Neurosci
April 2022
Department of Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, China.
Cureus
March 2022
Family and Community Medicine, Imam Abdulrahman Bin Faisal University, Dammam, SAU.
Background Liraglutide has pleiotropic effects beneficial to patients with cardiovascular and renal risks. These effects have been linked to weight and blood pressure reduction in type 2 diabetes (T2D) patients. However, whether this reduction is similar in all patients regardless of their ethnicity, baseline demographic, or clinical characteristics is unknown.
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