Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8815880PMC
http://dx.doi.org/10.1371/journal.pgen.1010048DOI Listing

Publication Analysis

Top Keywords

retraction pleiotropic
4
pleiotropic role
4
role drosophila
4
drosophila phosphoribosyl
4
phosphoribosyl pyrophosphate
4
pyrophosphate synthetase
4
synthetase autophagy
4
autophagy lysosome
4
lysosome homeostasis
4
retraction
1

Similar Publications

Platelet activation during hemostasis and thrombosis is facilitated by agonist-induced inside-out and integrin αβ-initiated outside-in signaling via protein kinases and phosphatases. Pharmacological inhibitor studies suggest that the serine/threonine protein phosphatase 1 (PP1) promotes platelet activation. However, since phosphatase inhibitors block all the isoforms of the catalytic subunit of PP1 (PP1c), the role of specific PP1c isoform in platelet signaling remains unclear.

View Article and Find Full Text PDF

Neurodegeneration: Microglia: Nf-Kappab Signaling Pathways.

Drug Res (Stuttg)

November 2022

Department of Pharmacology, Faculty of Pharmacy, Integral University, Lucknow (India).

Microglia is cells of mesodermal/mesenchymal origin that migrate into the central nervous system (CNS) to form resident macrophages inside the special brain microenvironment. Intact with both neuronal and non-neuronal cells, microglia is highly active cells. Continuous process extension and retraction allows microglia to scan the brain parenchyma for threats.

View Article and Find Full Text PDF
Article Synopsis
  • * Using data from large-scale genome-wide association studies (GWAS), the study examines genetic associations and identifies two shared pleiotropic genes that may influence both conditions.
  • * The research combines gene expression analysis and pathway enrichment to uncover twenty-five common biological processes connected to the overlap between epilepsy and depression, highlighting new potential pathways for further investigation.
View Article and Find Full Text PDF

Background Liraglutide has pleiotropic effects beneficial to patients with cardiovascular and renal risks. These effects have been linked to weight and blood pressure reduction in type 2 diabetes (T2D) patients. However, whether this reduction is similar in all patients regardless of their ethnicity, baseline demographic, or clinical characteristics is unknown.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!