Multivalent associative proteins with strong complementary interactions play a crucial role in phase separation of intracellular liquid condensates. We study the internal dynamics of such "bond-network" condensates comprising two complementary proteins via scaling analysis and molecular dynamics. We find that when stoichiometry is balanced, relaxation slows down dramatically due to a scarcity of alternative binding partners following bond breakage. This microscopic slow-down strongly affects the bulk diffusivity, viscosity, and mixing, which provides a means to experimentally test this prediction.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497325 | PMC |
| http://dx.doi.org/10.1103/PhysRevLett.128.038102 | DOI Listing |
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