AI Article Synopsis
- Large granular lymphocytic leukemia (LGLL) is a rare condition that originates from T or NK cells, and the study analyzed its diagnostic and treatment management over a 7-year period at a university hospital in France.
- In a cohort of fifteen patients, symptoms included neutropenia (8 patients), infections (4 patients), and some had additional conditions like rheumatoid arthritis and other hematological disorders.
- The findings showed significant variability in the detection and assessment of LGLL, demonstrating the complexity of the disease despite straightforward diagnostic methods.*
Article Abstract
Unlabelled: Large granular lymphocytic leukemia (LGLL) is a rare clonal lymphoproliferative disorder from T or NK origin.
Purpose: to report on the diagnostic and therapeutic management of LGLL investigated in the university hospital at Nancy, France.
Methods: retrospective (7 years) collection of clinical and biological data and patients' cohort analysis.
Results: Eight out of fifteen patients presented with neutropenia, including five profound neutropenia (neutrophils < 500 × 10/L). Four patients had an infection. Two patients have rheumatoid arthritis and an associated Felty's syndrome, one a Sweet syndrome. Two also suffered from chronic Lymphocytic Leukemia, and one from a diffuse large B-cell lymphoma. Twelve patients had LGLL-T and 3 had a chronic LGLL-NK. Eleven out of twelve patients had a clonal LGLL-T when polymerase chain reaction assessed. No KIR clonality was sought among the 3 LGL-NK patients. Five patients out of fifteen received immunosuppressive treatment.
Conclusion: Although using simple and robust investigations, our series demonstrates a high heterogeneity in LGLL detection and assessment.
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| http://dx.doi.org/10.1684/abc.2022.1701 | DOI Listing |
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