Particulate material is more efficient in eliciting immune responses. Here we describe the production of micro- and nanospheres formed by protein muNS-Mi from avian reoviruses, loaded with foreign epitopes for their use as vaccines.
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http://dx.doi.org/10.1007/978-1-0716-2168-4_2 | DOI Listing |
Int J Biol Macromol
January 2025
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210023, PR China. Electronic address:
Macromolecular glycopeptides are natural products derived from various sources, distinguished by their structural diversity, multifaceted biological activities, and low toxicity. These compounds exhibit a wide range of biological functions, such as immunomodulation, antitumor effects, anti-inflammatory properties, antioxidant activity, and more. However, limited understanding of natural glycopeptides has hindered their development and practical application.
View Article and Find Full Text PDFProtein Expr Purif
January 2025
Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi 981-8558, Japan. Electronic address:
Dectin-1 (CLEC7A), a C-type lectin-like receptor that recognizes β-1,3 glucans, has a key role in the innate immune system. While the lectin domain of mouse Dectin-1 has been solubilized and refolded from inclusion bodies in Escherichia coli, similar refolding of the human Dectin-1 lectin domain is hindered by the formation of misfolded multimers with aberrant intermolecular disulfide bonds. The aim of this study was to develop a method for the large-scale production of the human Dectin-1 lectin domain.
View Article and Find Full Text PDFChemosphere
January 2025
Chemical and Veterinary Analytical Institute Muensterland-Emscher-Lippe, Joseph-König-Str. 40, 48147, Muenster, Germany.
Perfluorocarboxylic acids and perfluorosulfonic acids accumulate in food webs, thus posing a serious threat to food safety. The European Food Safety Authority (EFSA) derived a tolerable weekly intake (TWI) of 4.4 ng/kg body weight for the sum of the four so-called EFSA-PFAS in 2020.
View Article and Find Full Text PDFInorg Chem
January 2025
Jiangxi Province Key Laboratory of Nuclear Physics and Technology, East China University of Technology, Nanchang 330013, China.
Recycling waste salt in the dry reprocessing of nuclear fuel and reducing electric energy consumption in the electrorefining process are crucial steps toward addressing significant challenges in this field. The present study proposes a novel approach to purify waste salt by selectively adsorbing excessive fission products using 5A molecular sieves (5A), based on the principles of electrorefining, with the ultimate aim of achieving sustainable development in nuclear fuel. First, Lutetium (Lu)-Bi alloy was synthesized through constant potential electrolysis in the LiCl-KCl-LuCl melt, resulting in a 90.
View Article and Find Full Text PDFJ Sep Sci
January 2025
Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Polycyclic aromatic hydrocarbons (PAHs) are carcinogenic compounds resulting from incomplete burning of organic materials. This work describes the successful layer-by-layer fabrication of a novel zinc oxide nanocomposite made of zinc oxide nanoparticles, aniline, sodium dodecyl sulfate, and modified multi-walled carbon nanotubes on a stainless steel wire by electrodeposition. The coating and extraction conditions were screened, optimized, and validated using factorial design and central composite design, respectively.
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