Cervical carcinoma high-expressed long non-coding RNA 1 promotes papillary thyroid carcinoma cell proliferation and invasion.

Background: Studies have shown that cervical carcinoma high-expressed long non-coding RNA 1 () may promote tumor development by regulating tumor migration and invasion in a variety of cancers; yet, the role of in papillary thyroid carcinoma (PTC) remains unclear. The purpose of this study was to explore the mechanism of in PTC.

Methods: The expression of in 51 PTC carcinoma tissues and normal adjacent tissues was measured using real-time quantitative polymerase chain reaction (RT-qPCR). Cell Counting Kit-8 (CCK8), plate cloning assay, transwell assay, and flow cytometry were used to analyze the effect of on PTC cell proliferation, invasion, and apoptosis .

Results: A higher expression of was found in PTC tissues than in adjacent tissues. High expression of was positively correlated with the number of tumors, extra-glandular invasion, and tumor stage. In addition, the down-regulation of reduced the proliferation and invasion of PTC cell lines and promoted cell apoptosis, while its up-regulation caused the opposite effect. These effects were regulated via the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) pathway.

Conclusions: The is closely related to PTC progression and may be used as a potential biomarker for early diagnosis and treatment of PTC.