Background: The purpose of this study was to investigate the efficacy and accuracy of magnetic resonance imaging (MRI) and contrast-enhanced computed tomography (CECT) for residual and new lesions after transcatheter arterial chemoembolization (TACE) in patients with primary liver cancer (PHC).
Methods: Seventy-two PHC patients admitted to Linyi Central Hospital from May 2018 to May 2020 were selected as the study subjects, with a total of 92 lesions. All patients were treated with TACE, and were followed up at 6 months postoperatively. In addition, all patients underwent digital subtraction angiography (DSA), and with DSA results serving as the gold standard for diagnosis, the efficacy and accuracy of MRI and CECT for residual and new lesions after TACE in PHC patients were evaluated.
Results: There were no significant differences in the specificity between the two diagnostic methods (P>0.05), and the diagnostic accuracy and sensitivity of MRI were markedly higher than those of CECT (P<0.05). The number of residual and new lesions diagnosed by MRI was notably higher than that by multislice spiral computed tomography (MSCT) (P<0.05), and the detection rate of residual and new lesions after TACE in PHC patients with different types of iodized oil deposition by MRI was significantly higher than that by CECT (P<0.05). Also, the number of postoperative tumor capsules diagnosed by MRI was considerably higher than that by CECT (P<0.05). There were no significant differences between the two diagnostic methods in the score of residual enhancement appearances in the arterial phase after surgery (P>0.05). Furthermore, there were no notable differences between the two diagnostic methods in the diagnosis of portal vein tumorous emboli and the source of blood supply to lesions after surgery (P>0.05).
Conclusions: The diagnostic accuracy and sensitivity of MRI for residual and new lesions after TACE in PHC patients were higher than those of CECT. However, these two diagnostic methods were similar in diagnosing portal vein tumorous emboli, the source of blood supply to lesions, and the score of residual enhancement appearances in the arterial phase after surgery.
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http://dx.doi.org/10.21037/tcr-21-831 | DOI Listing |
J Chem Inf Model
January 2025
State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200030, P.R. China.
The rise of resistance to antiretroviral drugs due to mutations in human immunodeficiency virus-1 (HIV-1) protease is a major obstacle to effective treatment. These mutations alter the drug-binding pocket of the protease and reduce the drug efficacy by disrupting interactions with inhibitors. Traditional methods, such as biochemical assays and structural biology, are crucial for studying enzyme function but are time-consuming and labor-intensive.
View Article and Find Full Text PDFJ Esthet Restor Dent
January 2025
Periodontology and Peri-Implant Diseases, Faculty of Medicine and Health Sciences of the University of Barcelona, Barcelona, Spain.
Objective: This study aimed to evaluate the efficacy and safety of a digitally guided dual technique during esthetic crown lengthening surgery. In addition, patient satisfaction and patient-reported outcomes were assessed.
Materials And Methods: A prospective case series study was conducted.
Curr Med Imaging
January 2025
Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Purpose: This study aimed to assess the hemodynamic changes in the vena cava and predict the likelihood of Cardiac Remodeling (CR) and Myocardial Fibrosis (MF) in athletes utilizing four-dimensional (4D) parameters.
Materials And Methods: A total of 108 athletes and 29 healthy sedentary controls were prospectively recruited and underwent Cardiac Magnetic Resonance (CMR) scanning. The 4D flow parameters, including both general and advanced parameters of four planes for the Superior Vena Cava (SVC) and Inferior Vena Cava (IVC) (sheets 1-4), were measured and compared between the different groups.
Biomark Res
January 2025
Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University180 Fenglin Road, Shanghai, 200032, China.
Background: Predicting the efficacy of immune-based therapy in patients with unresectable hepatocellular carcinoma (HCC) remains a clinical challenge. This study aims to evaluate the prognostic value of the systemic immune-inflammation index (SII) in forecasting treatment response and survival outcomes for HCC patients undergoing immune-based therapy.
Methods: We analyzed a cohort of 268 HCC patients treated with immune-based therapy from January 2019 to March 2023.
BMC Med Imaging
January 2025
Cancer Center, Department of Ultrasound Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, No. 158 Shang tang Road, Hangzhou, Zhejiang, 310011, China.
Background: This study aims to evaluate the predictive usefulness of a habitat radiomics model based on ultrasound images for anticipating lateral neck lymph node metastasis (LLNM) in differentiated thyroid cancer (DTC), and for pinpointing high-risk habitat regions and significant radiomics traits.
Methods: A group of 214 patients diagnosed with differentiated thyroid carcinoma (DTC) between August 2021 and August 2023 were included, consisting of 107 patients with confirmed postoperative lateral lymph node metastasis (LLNM) and 107 patients without metastasis or lateral cervical lymph node involvement. An additional cohort of 43 patients was recruited to serve as an independent external testing group for this study.
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